Recombinant HIV-1 TAT Clade-C
Produktgrößen
10 µg
£528,00
32-5588-10UG
Über dieses Produkt
- SKU:
- 32-5588
- Weitere Details:
- Source : Escherichia Coli. HIV-1 TAT Recombinant- produced in E.coli is a single; non-glycosylated; polypeptide chain containing 100 amino acids encoded by two exons and having chain having a molecular mass of 21 kDa. Human immunodeficiency virus type-1 (HIV-1) regulatory Tat protein plays an essential role in viral replication and infectivity. In addition; during acute infection; Tat is released extracellularly by infected cells and is taken up by neighboring cells where it transactivates viral replication and increases virus infectivity.HIV-1 Tat activates transcription of HIV-1 viral genes by inducing phosphorylation of the C-terminal domain (CTD) of RNA polymerase II (RNAPII). Tat can also disturb cellular metabolism by inhibiting proliferation of antigen-specific T lymphocytes and by inducing cellular apoptosis. Tat-induced apoptosis of T-cells is attributed; in part; to the distortion of microtubules polymerization. LIS1 is a microtubule-associated protein that facilitates microtubule polymerization.
- Aufreinigung:
- Greater than 90.0% as determined by SDS-PAGE.
- Versandbedingungen:
- Blue Ice
- Lagerbedingungen:
- HIV-1 TAT Clade-C recombinant although stable at 4[o]C for 1 week; should be stored below -18[o]C. Please prevent freeze-thaw cycles.
- Hersteller:
- Abeomics
- Typ:
- Proteins, Peptides, Small Molecules & Other Biomolecules:Recombinant Proteins
- Datenblatt des Herstellers:1.jpg