Recombinant Human STIP1 Homology and U-Box Containing Protein 1
Produktgrößen
50 µg
£528,00
32-5353-50UG
Über dieses Produkt
- SKU:
- 32-5353
- Zusätzliche Namen:
- CHIP||UBOX1||HSPABP2||NY-CO-7||SDCCAG7||STUB1||STIP1 homology and U box-containing protein 1||Carboxy terminus of Hsp70-interacting protein||E3 ubiquitin-protein ligase CHIP||CLL-associated antigen KW-8||Antigen NY-CO-7.
- Weitere Details:
- Source : Escherichia Coli. STUB1 Human Recombinant produced in E.Coli is a single; non-glycosylated polypeptide chain containing 303 amino acids and having a molecular mass of 34.8 kDa.STUB1 is expressed and purified by proprietary chromatographic techniques. STUB1; is a cytoplasmic protein whose amino acid sequence is highly preserved across species. STUB1 interacts with the molecular chaperones Hsc70-Hsp70 and Hsp90 through its TPR domain; whereas its U-box domain contains its E3 ubiquitin ligase activity. STUB1 interaction with these molecular chaperones lead to in client substrate ubiquitylation and degradation by the proteasome. therefore; STUB1 acts to tilt the folding-refolding mechanism towards the degradative pathway; and it serves as a link between the two. STUB1 inhibits anchorage-independent cell growth and metastatic potential by degrading oncogenic proteins including SRC-3. Inhibition of tyrosine kinase activity of Her-2/neu by quercetin specifies an lateration in the Her-2/neu structure which promotes STUB1 recruitments and down-regulation of Her-2/neu. STUB1 recognizes and mediates degradation of toxic; oligomeric forms of alphaSyn.
- Aufreinigung:
- Greater than 90.0% as determined by SDS-PAGE.
- Versandbedingungen:
- Blue Ice
- Lagerbedingungen:
- Store at 4[o]C if entire vial will be used within 2-4 weeks. Store; frozen at -20[o]C for longer periods of time. For long term storage it is recommended to add a carrier protein (0.1% HSA or BSA). Avoid multiple freeze-thaw cycles.
- Hersteller:
- Abeomics
- Typ:
- Proteins, Peptides, Small Molecules & Other Biomolecules
- Datenblatt des Herstellers:1.jpg