Human Zinc-Alpha 2 Glycoprotein
Produktgrößen
5 µg
£528,00
32-5267-5UG
Über dieses Produkt
- SKU:
- 32-5267
- Zusätzliche Namen:
- Zn-alpha-2-glycoprotein||Zn-alpha-2-GP||AZGP1||ZAG||Zinc-alpha-2-glycoprotein||ZNGP1||ZA2G.
- Weitere Details:
- Source : Human Serum. The Human Zinc-Alpha 2 Glycoprotein produced from Human Serum has a molecular mass of 32.14kDa (calculated without glycosylation) containing 278 amino acid residues. Zinc-alpha-2-glycoprotein (ZAG) is found in body fluids such as serum; sweat; and seminal and breast cyst fluids. It is identical in amino acid sequence to tumor-derived lipid mobilizing factor (LMF); a protein associated with the dramatic loss of adipose body stores in cancer cachexia; and has been shown to stimulate lipolysis by adipocytes in vivo and in vitro. A role for ZAG has been proposed in the regulation of body weight; and age-dependent changes in genetically influenced obesity; and also it regulates melanin production by normal and malignant melanocytes. It has also recently been classified as a novel adipokine in that it is produced by both white and brown fat adipocytes and may act in a local autocrine fashion in the reduction of adiposity in cachexia. Controlling ZAG/LMF's activity could be life-saving in the management of certain cancers and other cachexiainducing conditions; and its possible normal role in body fat store homeostasis is deserving of understanding in its own right. ZAG exhibits a class I major histocompatibility complex (MHC) fold but is a soluble protein rather than being anchored to plasma membranes and does not associate with alpha-2-microglobulin in humans. Like antigen-presenting MHC class I proteins; ZAG has an open apical groove; and X-ray crystallography of human derived ZAG revealed an unidentifiable electron density in a similar position to that occupied by antigenic peptides in classical MHC proteins and glycolipids in isoforms of CD1. This presumptive ligand is not a peptide; and the groove is too small to hold a glycolipid such as is presented by CD1 isoforms. By analogy with all other MHC class I-related proteins that have an open apical groove [some do not ]; occupancy by a ligand is probably crucial to ZAG's biological function. Despite all of the structural and biochemical evidence that ZAG binds a ligand; none has so far been found by extraction from protein isolated from biological fluids. This difficulty could be because the ligand is labile; heterogeneous; or readily lost during purification procedures. Knowing more about how ZAG interacts with the compounds it has been found to bind; both natural and artificial; will inform searches for the elusive ligand(s) and its/their role in ZAG's signaling function.
- Aufreinigung:
- Greater than 80% as determined by SDS-PAGE.
- Versandbedingungen:
- Blue Ice
- Lagerbedingungen:
- Store lyophilized protein at -20[o]C. Aliquot the product after reconstitution to avoid repeated freezing/thawing cycles. Reconstituted protein can be stored at 4[o]C for a limited period of time; it does not show any change after two weeks at 4[o]C.
- Hersteller:
- Abeomics
- Typ:
- Proteins, Peptides, Small Molecules & Other Biomolecules
- Datenblatt des Herstellers:1.jpg