Recombinant Human Zinc-Alpha 2 Glycoprotein
Produktgrößen
10 µg
£528,00
32-5266-10UG
Über dieses Produkt
- SKU:
- 32-5266
- Zusätzliche Namen:
- Zn-alpha-2-glycoprotein||Zn-alpha-2-GP||AZGP1||ZAG||Zinc-alpha-2-glycoprotein||ZNGP1||ZA2G.
- Weitere Details:
- Source : 293 Cell Line (Human Embryonic Kidney). ZA2G Human Recombinant produced in HEK cells is a single; glycosylated polypeptide chain containing a total of 290 amino acids encoding (13-290). ZA2G Human Recombinant is identical to Swiss-Prot-P25311 (AA 18-295; mature Zinc-Alpha-2-Glycoprotein). Twelve extra amino acids were fused with the N-terminus. Zinc-alpha-2-glycoprotein (ZAG) is found in body fluids such as serum; sweat; and seminal and breast cyst fluids. It is identical in amino acid sequence to tumor-derived lipid mobilizing factor (LMF); a protein associated with the dramatic loss of adipose body stores in cancer cachexia; and has been shown to stimulate lipolysis by adipocytes in vivo and in vitro. A role for ZAG has been proposed in the regulation of body weight; and age-dependent changes in genetically influenced obesity; and also it regulates melanin production by normal and malignant melanocytes. It has also recently been classified as a novel adipokine in that it is produced by both white and brown fat adipocytes and may act in a local autocrine fashion in the reduction of adiposity in cachexia. Controlling ZAG/LMF's activity could be life-saving in the management of certain cancers and other cachexiainducing conditions; and its possible normal role in body fat store homeostasis is deserving of understanding in its own right. ZAG exhibits a class I major histocompatibility complex (MHC) fold but is a soluble protein rather than being anchored to plasma membranes and does not associate with alpha-2-microglobulin in humans. Like antigen-presenting MHC class I proteins; ZAG has an open apical groove; and X-ray crystallography of human derived ZAG revealed an unidentifiable electron density in a similar position to that occupied by antigenic peptides in classical MHC proteins and glycolipids in isoforms of CD1. This presumptive ligand is not a peptide; and the groove is too small to hold a glycolipid such as is presented by CD1 isoforms. By analogy with all other MHC class I-related proteins that have an open apical groove [some do not ]; occupancy by a ligand is probably crucial to ZAG's biological function. Despite all of the structural and biochemical evidence that ZAG binds a ligand; none has so far been found by extraction from protein isolated from biological fluids. This difficulty could be because the ligand is labile; heterogeneous; or readily lost during purification procedures. Knowing more about how ZAG interacts with the compounds it has been found to bind; both natural and artificial; will inform searches for the elusive ligand(s) and its/their role in ZAG's signaling function.
- Aufreinigung:
- Greater than 90.0% as determined by:(a) Analysis by RP-HPLC. (b) Analysis by SDS-PAGE.
- Versandbedingungen:
- Blue Ice
- Lagerbedingungen:
- Lyophilized ZA2G although stable at room temperature for 3 weeks; should be stored desiccated below -18[o]C. Upon reconstitution ZA2G should be stored at 4[o]C between 2-7 days and for future use below -18[o]C. For long term storage it is recommended to add a carrier protein (0.1% HSA or BSA). Please avoid freeze-thaw cycles.
- Hersteller:
- Abeomics
- Typ:
- Proteins, Peptides, Small Molecules & Other Biomolecules
- Datenblatt des Herstellers:1.jpg