Recombinant Human Vav 1 Guanine Nucleotide Exchange Factor
Produktgrößen
10 µg
£528,00
32-5218-10UG
Über dieses Produkt
- SKU:
- 32-5218
- Zusätzliche Namen:
- Vav 1 Guanine Nucleotide Exchange Factor||VAV||Vav 1 Oncogene||Proto-Oncogene Vav.
- Weitere Details:
- Source : Escherichia Coli. VAV1 Human Recombinant produced in E.Coli is a single; non-glycosylated polypeptide chain containing 400 amino acids (189-565a.a) and having a molecular mass of 46.8kDa.VAV1 is fused to a 23 amino acid His-tag at N-terminus & purified by proprietary chromatographic techniques. Vav 1 Guanine Nucleotide Exchange Factor (VAV1); belongs to the VAV gene family. The VAV1 proteins are guanine nucleotide exchange factors (GEFs) for Rho family GTPases which activate pathways leading to actin cytoskeletal rearrangements and transcriptional alterations. VAV1 is essential in hematopoiesis; taking part in T-cell and B-cell development and activation. VAV1 has been identified as the specific binding partner of Nef proteins from HIV-1. In addition; VAV1 contains an SH2 domain; which could show its function as a substrate for tyrosine kinases. Expression of VAV1 is limited solely to cells of hematopoietic origin; as well as those of the erythroid; lymphoid and myeloid lineages. Among the diseases associated with VAV1 are cherubism; and hiv-1.
- Aufreinigung:
- "Greater than 85% as determined by SDS-PAGE."
- Versandbedingungen:
- Blue Ice
- Lagerbedingungen:
- Store at 4[o]C if entire vial will be used within 2-4 weeks. Store; frozen at -20[o]C for longer periods of time.For long term storage it is recommended to add a carrier protein (0.1% HSA or BSA).Please avoid freeze thaw cycles.
- Hersteller:
- Abeomics
- Typ:
- Molecular Biology Reagents:Nucleotides
- Datenblatt des Herstellers:1.jpg