Recombinant Human Usher Syndrome 1C
Produktgrößen
20 µg
£528,00
32-5201-20UG
Über dieses Produkt
- SKU:
- 32-5201
- Zusätzliche Namen:
- Harmonin||Usher syndrome type-1C protein||Autoimmune enteropathy-related antigen AIE-75||Antigen NY-CO-38/NY-CO-37||PDZ-73 protein||Renal carcinoma antigen NY-REN-3||USH1C||AIE75||PDZ73||AIE-75||DFNB18||PDZ-45||NY-CO-37||NY-CO-38||ush1cpst||PDZ-73/NY
- Weitere Details:
- Source : Escherichia Coli. USH1C Human Recombinant fused with a 37 amino acid His tag at N-terminus produced in E.Coli is a single; non-glycosylated; polypeptide chain containing 570 amino acids (1-533 a.a.) and having a molecular mass of 64.6kDa.The USH1C is purified by proprietary chromatographic techniques. USH1C gene product Harmonin; is a scaffold protein which functions in the assembly of Usher protein complexes. Harmonin is able to attach to various proteins in cell membranes and coordinate their activities. Harmonin contains PDZ domains; a coiled-coil region with a bipartite nuclear localization signal and a PEST degradation sequence. USH1C is expressed in the small intestine; colon; kidney; eye; vestibule of the inner ear and weakly in the pancreas. Mutations in the USH1C gene cause the Usher syndrome type I which is an autosomal recessive sensory defect involving congenital profound sensorineural deafness; vestibular dysfunction; and blindness due to progressive retinitis pigmentosa. Sensorineural deafness is caused by damage to the neural receptors of the inner ear; the nerve pathways to the brain; or the area of the brain that receives sound information. The 3 types of the Usher syndrome (1- 3) are distinguished by age at onset and differences in auditory and vestibular function. USH1C gene defects cause of non-syndromic sensorineural deafness autosomal recessive type 18 (DFNB18); is a form of sensorineural hearing loss.
- Aufreinigung:
- Greater than 95.0% as determined by SDS-PAGE.
- Versandbedingungen:
- Blue Ice
- Lagerbedingungen:
- Store at 4[o]C if entire vial will be used within 2-4 weeks. Store; frozen at -20[o]C for longer periods of time. For long term storage it is recommended to add a carrier protein (0.1% HSA or BSA).Avoid multiple freeze-thaw cycles.
- Hersteller:
- Abeomics
- Typ:
- Proteins, Peptides, Small Molecules & Other Biomolecules:Recombinant Proteins
- Datenblatt des Herstellers:1.jpg