Recombinant Human UL16 Binding Protein 2
Produktgrößen
20 µg
£528,00
32-5188-20UG
Über dieses Produkt
- SKU:
- 32-5188
- Zusätzliche Namen:
- UL16 binding protein 2||retinoic acid early transcript 1 H||NKG2D ligand 2||Retinoic acid early transcript 1H||ALCAN-alpha||N2DL-2||RAET1H.
- Weitere Details:
- Source : E.coli. ULBP2 Human Recombinant produced in E. coli is a single polypeptide chain containing 216 amino acids (26-216) and having a molecular mass of 24.3 kDa.ULBP2 is fused to a 25 amino acid His-tag at N-terminus & purified by proprietary chromatographic techniques. ULBP2 is a member of the MHC class I family. ULBP2 is ligand for the NKG2D receptor; composed with at least ULBP1 and ULBP3. ULBPs promote multiple signaling pathways in primary NK cells; triggering the production of cytokines and chemokines. Binding of ULBPs ligands to NKG2D encourages calcium mobilization and activation of the JAK2; STAT5; ERK and PI3K kinase/Akt signal transduction pathway. In CMV infected cells; ULBP2 cooperates with soluble CMV glycoprotein UL16. This cooperation is blocked with the NKG2D receptor; providing a mechanism in which CMV infected cells can escape the immune system. Additionally; UL16 causes ULBP2 to be held in the ER and cis-Golgi apparatus so that it does not reach the cell surface.
- Aufreinigung:
- Greater than 85% as determined by SDS-PAGE.
- Versandbedingungen:
- Blue Ice
- Lagerbedingungen:
- Store at 4[o]C if entire vial will be used within 2-4 weeks. Store; frozen at -20[o]C for longer periods of time. For long term storage it is recommended to add a carrier protein (0.1% HSA or BSA).Avoid multiple freeze-thaw cycles.
- Hersteller:
- Abeomics
- Typ:
- Proteins, Peptides, Small Molecules & Other Biomolecules
- Datenblatt des Herstellers:1.jpg