Recombinant Human Thrombospondin
Produktgrößen
10 µg
£583,00
32-5074-10UG
Über dieses Produkt
- SKU:
- 32-5074
- Zusätzliche Namen:
- Thrombospondin-1||THBS1||TSP||TSP1||THBS||THBS-1.
- Weitere Details:
- Source : Baculovirus Insect Cells. Recombinant Human THBS1 is glycosylated with N-linked sugars and produced using baculovirus vectors in insect cells. Recombinant Human THBS1 is Reactive with A4.1 anti-TSP mAb and its Mw is 140;000 Dalton. Thrombospondin-1 (TSP1) is a member of the Thrombospondin family and is encoded by the gene THBS1 which is a subunit of a disulfide-linked homotrimeric protein. Thrombospondin-1 is an adhesive glycoprotein that mediates cell-to-cell and cell-to-matrix interactions. Thrombospondin-1 can bind to fibrinogen; fibronectin; laminin; type V collagen and integrins alpha-V/beta-1. TSP1 has been shown to play roles in platelet aggregation; angiogenesis; and tumorigenesis. TSP1 has been shown to be a natural inhibitor of neovascularization and tumorigenesis in healthy tissue. TSP1 interacts with no less than 12 cell adhesion receptors; including CD36; av integrins; b1 integrins; syndecan; and integrin-associated protein (IAP or CD47). It also interacts with various proteases involved in angiogenesis; including plasminogen; urokinase; matrix metalloproteinase; thrombin; cathepsin; and elastase. Positive and negative modulation of endothelial cell adhesion; motility; and growth are attributed to TSP1. Recently; thrombospondin-1 was found to bind to the reelin receptors; ApoER2 and VLDLR; in so doing affecting neuronal migration in the rostral migratory stream.
- Aufreinigung:
- Greater than 90.0% as determined by:(a) Analysis by RP-HPLC.(b) Analysis by SDS-PAGE.
- Versandbedingungen:
- Blue Ice
- Lagerbedingungen:
- Recombinant Human TSP should be stored between 2[o]C- 8[o]C. For long term storage it is recommended to add a carrier protein (0.1% HSA or BSA).
- Hersteller:
- Abeomics
- Typ:
- Proteins, Peptides, Small Molecules & Other Biomolecules:Recombinant Proteins
- Datenblatt des Herstellers:1.jpg