Recombinant Human T-cell Leukemia/Lymphoma 1A
Produktgrößen
50 µg
£528,00
32-5053-50UG
Über dieses Produkt
- SKU:
- 32-5053
- Zusätzliche Namen:
- T-cell leukemia/lymphoma protein 1A||Protein p14 TCL1||Oncogene TCL-1||Oncogene TCL1||TCL1A||TCL1.
- Weitere Details:
- Source : Escherichia Coli. TCL1A Human Recombinant produced in E.Coli is a single; non-glycosylated; polypeptide chain containing 114 amino acids (1-114 a.a.) and having a molecular mass of 13.4kDa.The TCL1A is purified by proprietary chromatographic techniques. TCL1A (T-cell leukemia/lymphoma 1A) is a protein with a possible role in intracellular regulation of T cell signaling. TCL1A enhances cell proliferation; stabilizes mitochondrial membrane potential and promotes cell survival. TCL1A is restricted in the T-cell lineage to immature thymocytes and activated peripheral lymphocytes. TCL1A is preferentially expressed early in T and B-lymphocyte differentiation. Chromosomal anomalies activating TCL1A are found in chronic T-cell leukemias (T-CLL). TCL1A enhances the phosphorylation and activation of AKT1; AKT2 and AKT3. TCL1A promotes nuclear translocation of AKT1. TCL1A binds to the pleckstrin homology domain of Akt (protein kinase B) family proteins; which facilitates Akt dimerization and activity. By increasing Akt activity; TCL1A can enhance the serine/threonine phosphorylation of major Akt signaling substrates; for example Ikk complex; mTOR; BAD; p70S6 kinase; FOXO transcription factors and GSK3b. These substrates regulate cellular differentiation; growth; survival; and metabolism.
- Aufreinigung:
- Greater than 90.0% as determined by SDS-PAGE.
- Versandbedingungen:
- Blue Ice
- Lagerbedingungen:
- TCL1A although stable 4[o]C for 4 weeks; should be stored desiccated below -18[o]C. For long term storage it is recommended to add a carrier protein (0.1% HSA or BSA).Please prevent freeze-thaw cycles.
- Hersteller:
- Abeomics
- Typ:
- Proteins, Peptides, Small Molecules & Other Biomolecules:Recombinant Proteins
- Datenblatt des Herstellers:1.jpg