Recombinant Human Stromal Interaction Molecule 1
Produktgrößen
25 µg
£528,00
32-4980-25UG
Über dieses Produkt
- SKU:
- 32-4980
- Zusätzliche Namen:
- Stromal interaction molecule 1||GOK||D11S4896E||STIM-1||STIM1.
- Weitere Details:
- Source : Escherichia Coli. Recombinant STIM1 produced in E.Coli is a single; non-glycosylated polypeptide chain containing 343 amino acids and having a molecular mass of 38 kDa. STIM1 is fused to Calmodulin and purified by conventional chromatography techniques. STIM1 is a type-1 transmembrane protein that is necessary for store-operated Ca(2+) entry; a process of extracellular Ca(2+) influx in response to the depletion of Ca(2+) stores in the endoplasmic reticulum (ER). STIM1 localizes predominantly to the ER; upon Ca(2+) release from the ER; STIM1 translocates to the ER-plasma membrane junctions and activates Ca(2+) channels. STIM1 is an adhesion molecule involved in early hematopoiesis by mediating attachment to stromal cells. STIM1 controls the survival and/or proliferation of b-cell precursors. STIM1 gene is one of several genes located in the imprinted gene domain of 11p15.5; a significant tumor-suppressor gene region. Alterations in this region have been associated with the Beckwith-Wiedemann syndrome; Wilms tumor; rhabdomyosarcoma; adrenocrotical carcinoma; and lung; ovarian; and breast cancer. STIM1 is involved in malignancies as well as early hematopoiesis; by mediating attachment to stromal cells. STIM1 is oriented in a head-to-tail configuration with the ribonucleotide reductase 1 gene (RRM1); with the 3' end of this gene situated 1.6 kb from the 5' end of the RRM1 gene.
- Aufreinigung:
- Greater than 90.0% as determined by(a) Analysis by RP-HPLC.(b) Analysis by SDS-PAGE.
- Versandbedingungen:
- Blue Ice
- Lagerbedingungen:
- Store at 4[o]C if entire vial will be used within 2-4 weeks. Store; frozen at -20[o]C for longer periods of time. For long term storage it is recommended to add a carrier protein (0.1% HSA or BSA). Avoid multiple freeze-thaw cycles.
- Hersteller:
- Abeomics
- Typ:
- Proteins, Peptides, Small Molecules & Other Biomolecules:Recombinant Proteins
- Datenblatt des Herstellers:1.jpg