Recombinant Human Signal Recognition Particle 54kDa
Produktgrößen
20 µg
£528,00
32-4962-20UG
Über dieses Produkt
- SKU:
- 32-4962
- Zusätzliche Namen:
- Signal Recognition Particle 54 kDa protein
- Weitere Details:
- Source : Sf9 insect cells. SRP54 is a full-length cDNA coding for the human SRP54 protein having a molecular mass of 56;528 Dalton (pH 8.9). SRP54 protein is fused to a hexa-histidine purification tag. SRP54 is a 54-kDa subunit of the signal recognition particle (SRP); a cytoplasmic ribonucleoprotein complex which leads the translocation of newly synthesized secretory proteins from the polysome to the endoplasmic reticulum. SRP is composed of six polypeptides and a tRNA-like molecule known as 7SL RNA. SRP54 is a GTP-binding protein that directly binds the signal sequences of nascent secretory and membrane proteins. Anti-SRP autoantibodies take place in patients with an autoimmune chronic muscle inflammation called polymyositis. These auto-antibodies predominantly recognize the SRP54 subunit and in addition are able to immunoprecipitate several of the SRP subunits and the RNA component. Nearly 5% of myositis patients are positive for anti-SRP autoantibodies; increasing to 18% in the subgroup of Jo-1 autoantibody-negative patients. The classic 'anti-SRP syndrome' is a severe form of polymyositis in which the myositic inflammation is acute and aggressive onset; with common myalgias and cardiac involvement. Normally there is a poor reaction to therapy with a 5-year survival rate of about 25%.
- Aufreinigung:
- Greater than 80% as determined by SDS-PAGE.
- Versandbedingungen:
- Blue Ice
- Lagerbedingungen:
- Store at 4[o]C if entire vial will be used within 2-4 weeks. Store; frozen at -20[o]C for longer periods of time. Avoid multiple freeze-thaw cycles.
- Hersteller:
- Abeomics
- Typ:
- Proteins, Peptides, Small Molecules & Other Biomolecules:Recombinant Proteins
- Datenblatt des Herstellers:1.jpg