Recombinant Human Secreted Protein Acidic & Rich in Cysteine
Produktgrößen
50 µg
£528,00
32-4941-50UG
Über dieses Produkt
- SKU:
- 32-4941
- Zusätzliche Namen:
- Osteonectin||ON||Basement-membrane protein 40||BM-40||SPARC||Secreted Protein acidic and Rich in Cysteine.
- Weitere Details:
- Source : Escherichia Coli. Osteonectin Human Recombinant fused with 6X His tag produced in E.Coli is a single; non-glycosylated; polypeptide chain containing 295 amino acids and having a molecular mass of 34 kDa.The BM40 is purified by proprietary chromatographic techniques. SPARC; an acronym for 'secreted protein; acidic and rich in cysteine'; is also known as osteonectin or BM-40. It is the founding member of a family of secreted matricellular proteins with similar domain structure. The 303 amino acid; 43 kDa protein contains a 17 aa signal sequence; an N-terminal acidic region that binds calcium; a follistatin domain containing Kazal-like sequences; and a C-terminal extracellular calcium (EC) binding domain with two EF-hand motifs. SPARC is produced by fibroblasts; capillary endothelial cells; platelets and macrophages; especially in areas of tissue morphogenesis and remodeling. SPARC shows context-specific effects; but generally inhibits adhesion; spreading and proliferation; and promotes collagen matrix formation. For endothelial cells; SPARC disrupts focal adhesions and binds and sequesters PDGF and VEGF. SPARC is abundantly expressed in bone; where it promotes osteoblast differentiation and inhibits adipogenesis.
- Aufreinigung:
- Greater than 95.0% as determined by:(a) Analysis by RP-HPLC.(b) Analysis by SDS-PAGE.
- Versandbedingungen:
- Blue Ice
- Lagerbedingungen:
- Lyophilized Osteonectin although stable at room temperature for 3 weeks; should be stored desiccated below -18[o]C. Upon reconstitution BM-40 should be stored at 4[o]C between 2-7 days and for future use below -18[o]C.For long term storage it is recommended to add a carrier protein (0.1% HSA or BSA).Please prevent freeze-thaw cycles.
- Hersteller:
- Abeomics
- Typ:
- Proteins, Peptides, Small Molecules & Other Biomolecules
- Datenblatt des Herstellers:1.jpg