Recombinant Human Secreted Frizzled-Related Protein 4
Produktgrößen
10 µg
£528,00
32-4828-10UG
Über dieses Produkt
- SKU:
- 32-4828
- Zusätzliche Namen:
- Secreted frizzled-related protein 4||sFRP-4||Frizzled protein||human endometrium||FrpHE||SFRP4||FRPHE||FRP-4.
- Weitere Details:
- Source : HEK 293. SFRP4 Human Recombinant produced in HEK cells is a single; glycosylated; polypeptide chain (a.a 19-346) containing a total of 341 amino acids; having a molecular mass of 39kDa (calculated); though it migrates at approximately 55kDa on SDS PAGE; the SFRP4 is fused to a 5 a.a N-terminal linker and an 8 a.a Flag tag at N-Terminus.The Human SFRP4 is purified by proprietary chromatographic techniques. Secreted frizzled-related protein 4 (SFRP4) belongs to the SFRP family which contains a cysteine-rich domain homologous to the putative Wnt-binding site of Frizzled proteins. SFRPs serve as soluble modulators of Wnt signaling. SFRP4 may serve as a regulator of adult uterine morphology and function. SFRP4 increases apoptosis during ovulation possibly via modulation of FZ1/FZ4/WNT4 signaling. SFRP4 also has phosphaturic effects by specifically inhibiting sodium-dependent phosphate uptake. SFRP4 is expressed in proliferative endometrium and several types of ovarian; endometrial and Brest tumors. SFRP4 is expressed in mesenchymal cells and in cardiomyocytes. SFRP4 expression in ventricular myocardium correlates with apoptosis related gene expression. SFRP4 is up-regulated in failing myocardium.
- Aufreinigung:
- Greater than 90.0% as determined by SDS-PAGE.
- Versandbedingungen:
- Blue Ice
- Lagerbedingungen:
- Store lyophilized protein at -20[o]C. Aliquot the product after reconstitution to avoid repeated freezing/thawing cycles. Reconstituted protein can be stored at 4[o]C for a limited period of time; it does not show any change after two weeks at 4[o]C.
- Hersteller:
- Abeomics
- Typ:
- Proteins, Peptides, Small Molecules & Other Biomolecules
- Datenblatt des Herstellers:1.jpg