Recombinant Human S100 Calcium Binding Protein B
Produktgrößen
20 µg
£528,00
32-4755-20UG
Über dieses Produkt
- SKU:
- 32-4755
- Zusätzliche Namen:
- Protein S100-B||S100 calcium-binding protein B||S-100 protein subunit beta||S-100 protein beta chain||S100B||NEF||S100||S100beta.
- Weitere Details:
- Source : Escherichia Coli. S100B Human Recombinant produced in E.Coli is single; a non-glycosylated; Polypeptide chain containing 112 amino acids fragment (1-92) with a 20 amino acids N-terminal His tag and having a total molecular mass of 12.8kDa. The S100B is purified by proprietary chromatographic techniques. S100b is a member of the S100 family of proteins which are a family of EF-hand calcium binding proteins that exist mostly as dimers of the 20 currently identified individual S100 monomers. The S100B homodimer is expressed in cells of the central nervous system; glial cells and in certain peripheral cells e.g. Schwann cells; melanocytes; adipocytes and chondrocytes. S100 proteins are localized either in the cytoplasm or the nucleus of a wide range of cells. S100 proteins are involved in the regulation of a number of cellular processes such as cell cycle progression and differentiation. There are at least 13 members in the S100 gene family; which are located as a cluster on chromosome 1q21; however; S100b is located at 21q22.3. The determination of S100B in serum levels may be used to monitor the extent of brain injury and malignant melanoma. S100b proteins may have a role in Neurite extension; proliferation of melanoma cells; stimulation of Ca2+ fluxes; inhibition of PKC-mediated phosphorylation; astrocytosis and axonal proliferation; and inhibition of microtubule assembly. Chromosomal rearrangements and altered expression of the S100b gene are implicated in several neurological; neoplastic; and other types of diseases; including Alzheimer's disease; Down's syndrome; epilepsy; amyotrophic lateral sclerosis; melanoma; and type I diabetes.
- Aufreinigung:
- Greater than 90.0% as determined by SDS-PAGE.
- Versandbedingungen:
- Blue Ice
- Lagerbedingungen:
- Store at 4[o]C if entire vial will be used within 2-4 weeks. Store; frozen at -20[o]C for longer periods of time. For long term storage it is recommended to add a carrier protein (0.1% HSA or BSA).Avoid multiple freeze-thaw cycles.
- Hersteller:
- Abeomics
- Typ:
- Proteins, Peptides, Small Molecules & Other Biomolecules
- Datenblatt des Herstellers:1.jpg