Recombinant Human Related RAS Viral (r-ras) Oncogene Homolog 2
Produktgrößen
50 µg
£528,00
32-4714-50UG
Über dieses Produkt
- SKU:
- 32-4714
- Zusätzliche Namen:
- Ras-related protein R-Ras2||Ras-like protein TC21||Teratocarcinoma oncogene||RRAS2||TC21.
- Weitere Details:
- Source : Escherichia Coli. RRAS2 Human Recombinant fused with a 20 amino acid His tag at N-terminus produced in E.Coli is a single; non-glycosylated; polypeptide chain containing 221 amino acids (1-201 a.a.) and having a molecular mass of 25.2 kDa.The RRAS2 is purified by proprietary chromatographic techniques. RRAS2 (RAS viral (r-ras) oncogene homolog 2) is a member of the Ras like GTPase family that cycle between GTP-bound active and GDP-bound inactive states at the cytoplasmic face of the plasma membrane. RRAS2 is a plasma membrane-associated GTP-binding protein with GTPase activity. RRAS2 is implicated in the pathogenesis of human cancers. Hence; overexpression of active RRAS2 in EpH4 cells induces tumorigenicity through the phosphoinositide 3-kinase; p38 MAPK; and mTOR pathways; as these cells lose their sensitivity to the normal growth inhibitory role of TGF-beta. RRAS2 might transduce growth inhibitory signals across the cell membrane; exerting its effect via an effector shared with the Ras proteins but in an antagonistic manner.RRAS2 is ubiquitously present in all tissues examined; with the highest levels in the heart; placenta; and skeletal muscle. Moderate levels of RRAS2 are found in the lung and liver and low levels in the brain; kidney; and pancreas.RRAS2 deficiencies are linked to ovarian cancer.
- Aufreinigung:
- Greater than 95.0% as determined by SDS-PAGE.
- Versandbedingungen:
- Blue Ice
- Lagerbedingungen:
- Store at 4[o]C if entire vial will be used within 2-4 weeks.Store; frozen at -20[o]C for longer periods of time. For long term storage it is recommended to add a carrier protein (0.1% HSA or BSA).Avoid multiple freeze-thaw cycles.
- Hersteller:
- Abeomics
- Typ:
- Proteins, Peptides, Small Molecules & Other Biomolecules:Recombinant Proteins
- Datenblatt des Herstellers:1.jpg