Recombinant Human Regenerating Islet-Derived 1 Beta
Produktgrößen
10 µg
£528,00
32-4632-10UG
Über dieses Produkt
- SKU:
- 32-4632
- Zusätzliche Namen:
- Lithostathine-1-beta||Regenerating protein I beta||REG1B||REGL.
- Weitere Details:
- Source : Escherichia Coli. The Recombinant Human REG 1 beta manufactured with N-terminal fusion of His Tag. The Human REG 1 beta His-Tagged Fusion Protein; produced in E. coli; is 17.8 kDa protein containing 144 amino acid residues of the Human REG 1 beta and 12 additional amino acid residues - His Tag . Reg protein was shown to be stimulated during the regeneration of pancreatic islets. Since then; many Reg-related proteins have been identified in humans and other animals. In human; the four REG family genes; i.e.; REG 1 alpha; REG 1 beta; REG-related sequence (RS) and HIP/PAP; have so far been isolated. These Reg-related proteins are classified into four subfamilies according to their amino-acid sequences; but they share a similar structure and physiological function. Reg protein is a growth factor for pancreatic beta cells and also suggests that the administration of Reg protein could be used as another therapeutic approach for diabetes mellitus. Human REG cDNA which encodes a 166-amino acid protein with a 22-amino acid signal peptide. The amino acid sequence of human REG protein has 68% homology to that of rat Reg protein.Reg I was found to be expressed mainly in pancreatic beta and acinoductular cells as well as gastric fundic enterochromaffin-like (ECL) cells. Reg I production in ECL cells is stimulated by gastrin; as well as by the proinflammatory cytokine; cytokine-induced neutrophil chemoattractant (CINC)-2Beta. In patients with chronic hypergastrinemia; Reg production is stimulated; with the increased proliferation of gastric mucosal cells. Patients with Helicobacter pylori infection also showed increased Reg production in the gastric mucosa; partly via increased plasma gastrin concentration and partly via increased proinflammatory cytokine production. The serum concentration of the reg-protein was significantly higher in patients with various pancreatic diseases than in normal controls; and was also significantly higher in patients with acute pancreatitis or chronic relapsing pancreatitis than in patients with chronic pancreatitis. Furthermore; the serum PSP/reg-protein concentration was also significantly increased in liver cirrhosis; choledocholithiasis; and various cancers of the digestive system.
- Aufreinigung:
- Greater than 95% as determined by SDS-PAGE.
- Versandbedingungen:
- Blue Ice
- Lagerbedingungen:
- Store lyophilized protein at -20[o]C. Aliquot the product after reconstitution to avoid repeated freezing/thawing cycles. Reconstituted protein can be stored at 4[o]C for a limited period of time; it does not show any change after two weeks at 4[o]C.
- Hersteller:
- Abeomics
- Typ:
- Proteins, Peptides, Small Molecules & Other Biomolecules:Recombinant Proteins
- Datenblatt des Herstellers:1.jpg