Recombinant Human Pellino E3 Ubiquitin Protein Ligase Family Member 2
Produktgrößen
10 µg
£528,00
32-4430-10UG
Über dieses Produkt
- SKU:
- 32-4430
- Zusätzliche Namen:
- Pellino E3 Ubiquitin Protein Ligase Family Member 2||Pellino-2; E3 Ubiquitin-Protein Ligase Pellino Homolog 2||Pellino (Drosophila) Homolog 2||Pellino Homolog 2 (Drosophila)||Protein Pellino Homolog 2||Pellino Homolog 2||EC 6.3.2; PELI2.
- Weitere Details:
- Source : Escherichia Coli. PELI2 Human Recombinant produced in E.Coli is a single; non-glycosylated polypeptide chain containing 443 amino acids (1-420 a.a) and having a molecular mass of 48.8kDa. PELI2 is fused to a 23 amino acid His-tag at N-terminus & purified by proprietary chromatographic techniques. Pellino E3 Ubiquitin Protein Ligase Family Member 2; also known as PELI2 is an E3 ubiquitin ligase which catalyzes the covalent attachment of ubiquitin moieties onto substrate proteins. PELI2 is implicated in the TLR and IL-1 signaling pathways through interaction with the complex which contain IRAK kinases and TRAF6. PELI2 also mediates IL1B-induced IRAK1 'Lys-63'-linked polyubiquitination and possibly 'Lys-48'-linked ubiquitination. PELI2 is significant for LPS- and IL1B-induced MAP3K7-dependent; however not for MAP3K3-dependent; NF-kappa-B activation. Moreover; PELI2 can activate the MAP (mitogen activated protein) kinase pathway directing to activation of ELK1.
- Aufreinigung:
- "Greater than 80.0% as determined by SDS-PAGE."
- Versandbedingungen:
- Blue Ice
- Lagerbedingungen:
- Store at 4[o]C if entire vial will be used within 2-4 weeks. Store; frozen at -20[o]C for longer periods of time. For long term storage it is recommended to add a carrier protein (0.1% HSA or BSA).Avoid multiple freeze-thaw cycles.
- Hersteller:
- Abeomics
- Typ:
- Proteins, Peptides, Small Molecules & Other Biomolecules
- Datenblatt des Herstellers:1.jpg