Recombinant Human Phosphoprotein Enriched in Astrocytes 15
Produktgrößen
10 µg
£528,00
32-4427-10UG
Über dieses Produkt
- SKU:
- 32-4427
- Zusätzliche Namen:
- Astrocytic phosphoprotein PEA-15||15 kDa phosphoprotein enriched in astrocytes||Phosphoprotein enriched in diabetes||PED||PEA15||MAT1||HMAT1||MAT1H||PEA-15||HUMMAT1H.
- Weitere Details:
- Source : Escherichia Coli. PEA15 Human Recombinant produced in E.Coli is a single; non-glycosylated; polypeptide chain containing 130 amino acids (1-130 a.a.) and having a molecular mass of 15kDa.The PEA15 is purified by proprietary chromatographic techniques. PEA15 (Phospho-enriched protein in astrocytes 15kDa) is a death effector domain (DED)-containing protein mainly expressed in the central nervous system; principally in astrocytes. PEA15 is implicated in the regulation of various cellular processes including apoptosis; proliferation; glucose transport; adhesion and migration. PEA15 regulates glucose transport by controlling both the content of SLC2A1 glucose transporters on the plasma membrane and the insulin-dependent trafficking of SLC2A4 from the cell interior to the surface. Increased PEA15 levels have an affect tumorigenesis and cancer progression; therefore it is overexpressed in breast cancers and gliomas as well as in type 2 diabetes. PEA15 blocks Ras-mediated inhibition of integrin activation and modulates the ERK MAP kinase cascade. PEA15 also inhibits RPS6KA3 activities by holding it in the cytoplasm. In addition; PEA15 inhibits both TNFRSF6 and TNFRSF1A mediated CASP8 activity and apoptosis. PEA15 is ubiquitously expressed. PEA15 is most abundant in tissues such as the heart; brain; muscle and adipose tissue which use glucose as an energy source. Lower PEA15 expression is in glucose-producing tissues. Higher levels of PEA15 expression are found in tissues from individuals with type 2 diabetes than in controls.PEA15 expression is a significant prognostic marker in ovarian cancer.
- Aufreinigung:
- Greater than 90.0% as determined by SDS-PAGE.
- Versandbedingungen:
- Blue Ice
- Lagerbedingungen:
- Store at 4[o]C if entire vial will be used within 2-4 weeks.Store; frozen at -20[o]C for longer periods of time. For long term storage it is recommended to add a carrier protein (0.1% HSA or BSA).Please prevent freeze-thaw cycles.
- Hersteller:
- Abeomics
- Typ:
- Proteins, Peptides, Small Molecules & Other Biomolecules
- Datenblatt des Herstellers:1.jpg