Recombinant Human Osteocrin
Produktgrößen
10 µg
£528,00
32-4382-10UG
Über dieses Produkt
- SKU:
- 32-4382
- Zusätzliche Namen:
- Osteocrin||Musclin||OSTN.
- Weitere Details:
- Source : Escherichia Coli. The recombinant Human Osteocrin is produced with N-terminal fusion of His Tag. The Human Osteocrin His-Tagged Fusion Protein is 13.6 kDa containing 106 amino acid residues of the human Osteocrin and 16 additional amino acid residues - His Tag . Osteocrin is a recently identified secreted protein expression of which was only detected in bone; peaking just after birth and decreasing markedly with age. A 1280-bp mRNA encodes osteocrin producing a mature protein of 103 amino acids with a molecular mass of 11.4 kDa. In primary osteoblastic cell cultures osteocrin expression coincided with matrix formation then decreased in very mature cultures. Treatment of cultures with 1;25-dihydroxyvitamin D3 resulted in a rapid dose- dependent down-regulation of osteocrin expression; suggesting direct regulation. Chronic treatment of primary cultures with osteocrin-conditioned media inhibited mineralization and reduced osteocalcin and alkaline phosphatase expression. These results suggest that osteocrin represents a novel; unique vitamin D-regulated bone-specific protein that appears to act as a soluble osteoblast regulator.
- Aufreinigung:
- Greater than 95% as determined by SDS-PAGE.
- Versandbedingungen:
- Blue Ice
- Lagerbedingungen:
- Store lyophilized protein at -20[o]C. Aliquot the product after reconstitution to avoid repeated freezing/thawing cycles. Reconstituted protein can be stored at 4[o]C for a limited period of time; it does not show any change after two weeks at 4[o]C.
- Hersteller:
- Abeomics
- Typ:
- Proteins, Peptides, Small Molecules & Other Biomolecules:Recombinant Proteins
- Datenblatt des Herstellers:1.jpg