Recombinant Human Nucleic Acid Binding Protein 1
Produktgrößen
20 µg
£528,00
32-4278-20UG
Über dieses Produkt
- SKU:
- 32-4278
- Zusätzliche Namen:
- Nucleic Acid Binding Protein 1||OBFC2A||Sensor Of Single-Strand DNA Complex Subunit B2||Single-Stranded DNA-Binding Protein 2||SSB2; Oligonucleotide/Oligosaccharide-Binding Fold Containing 2A||Nucleic Acid-Binding Protein 1||Oligonucleotide/Oligosacc
- Weitere Details:
- Source : Escherichia Coli. NABP1 Human Recombinant produced in E.Coli is a single; non-glycosylated polypeptide chain containing 227 amino acids (1-204 a.a) and having a molecular mass of 24.8kDa.NABP1 is fused to a 23 amino acid His-tag at N-terminus & purified by proprietary chromatographic techniques. Nucleic acid binding protein 1 is a part of the SOSS complex; a multiprotein complex which functions downstream of the MRN complex to promote DNA repair and G2/M checkpoint. In the SOSS complex; NABP1 acts as a sensor of single-stranded DNA which binds to single-stranded DNA; in particular to polypyrimidines. The SOSS complex links with DNA lesions and affects diverse endpoints in the cellular DNA damage response including cell-cycle checkpoint activation; recombinational repair and maintenance of genomic stability. NABP1 is essential for efficient homologous recombination-dependent repair of double-strand breaks (DSBs) and ATM-dependent signaling pathways.
- Aufreinigung:
- Greater than 95.0% as determined by SDS-PAGE.
- Versandbedingungen:
- Blue Ice
- Lagerbedingungen:
- Store at 4[o]C if entire vial will be used within 2-4 weeks. Store; frozen at -20[o]C for longer periods of time. For long term storage it is recommended to add a carrier protein (0.1% HSA or BSA). Avoid multiple freeze-thaw cycles.
- Hersteller:
- Abeomics
- Typ:
- Proteins, Peptides, Small Molecules & Other Biomolecules
- Datenblatt des Herstellers:1.jpg