Recombinant Human Methyl CpG Binding Protein 2
Produktgrößen
10 µg
£528,00
32-4190-10UG
Über dieses Produkt
- SKU:
- 32-4190
- Zusätzliche Namen:
- Methyl CpG binding protein 2 (Rett syndrome)||MeCp-2 protein||AUTSX3||MRX16||MRX79||MRXS13||MRXSL||PPMX||RTT||Mental retardation||X-linked 16||DKFZp686A24160.
- Weitere Details:
- Source : Mammalian system; 293 cells. MECP2 Human Recombinant is expressed in 293 cells. The protein contains 486 amino acids (1-486a.a.) and fused to an N-terminal Flag tag; having an Mw of 53.56kDa. MECP2 is the key modificator of eukaryotic genomes and has a crucial part in mammalian development. Human proteins MECP2; MBD1; MBD2; MBD3; and MBD4 form a family of nuclear proteins linked by the existence in each of a methyl-CpG binding domain (MBD). Each one of these proteins; with the exception of MBD3; can bind specifically to methylated DNA. In addition; MECP2; MBD1 and MBD2 can inhibit transcription from methylated gene promoters. Unlike other MBD family members; MECP2 is X-linked and subject to X inactivation. MECP2 is expendable in stem cells; but is vital for embryonic development. MECP2 gene mutations are the cause of most cases of Rett syndrome; a progressive neurologic developmental disorder and one of the most common reasons of mental retardation in females.
- Aufreinigung:
- Greater than 80% as determined by SDS-PAGE.
- Versandbedingungen:
- Blue Ice
- Lagerbedingungen:
- MECP2 although stable 4[o]C for 4 weeks; should be stored below -18[o]C. For long term storage it is recommended to add a carrier protein (0.1% HSA or BSA).Please prevent freeze-thaw cycles.
- Hersteller:
- Abeomics
- Typ:
- Proteins, Peptides, Small Molecules & Other Biomolecules
- Datenblatt des Herstellers:1.jpg