Recombinant Human L-Selectin
Produktgrößen
10 µg
£528,00
32-4127-10UG
Über dieses Produkt
- SKU:
- 32-4127
- Zusätzliche Namen:
- L-selectin||Lymph node homing receptor||Leukocyte adhesion molecule 1||LAM-1||Leukocyte surface antigen Leu-8||TQ1||gp90-MEL||Leukocyte-endothelial cell adhesion molecule 1||LECAM1||CD62 antigen-like family member L||CD62L antigen||LAM1||LNHR||LSEL||
- Weitere Details:
- Source : Escherichia Coli. L-Selectin Human Recombinant is expressed in E. coli containing 294 amino acids 39-332 fused to an amino terminal hexahistidine tag; having a total molecular weight of 37.55kDa. L-Selectin belongs to a family of divalent cation-dependent carbohydrate-binding glycoproteins or adhesion molecules. The L-Selectin molecule is composed of various domains: one homologous to lectins; one to epidermal growth factor; and two to the consensus repeat units found in C3/C4 binding proteins.L-selectin is expressed constitutively on lymphocytes; monocytes and granulocytes and interacts specifically with carbohydrate groups on activated endothelial cells. L-Selectin may be shed by proteolytic cleavage and circulating levels in biological fluids may be used as an indicator of various pathological conditions. L-Selectin is cleaved by ADAM17.L-selectin works as a 'homing receptor' for leukocytes to enter secondary lymphoid tissues via the high endothelial venules. Ligands present on endothelial cells will attach to leukocytes expressing L-selectin; which causes the leukocytes to become localized at that juncture. The receptor is also located on the cell surfaces of 'naive' T cells; which have not yet encountered their particular antigen. This surface expression is lost following the cells activation.
- Aufreinigung:
- Greater than 95% as determined by SDS-PAGE. Single band on Western Blot.
- Versandbedingungen:
- Blue Ice
- Lagerbedingungen:
- Store at 4[o]C if entire vial will be used within 1-2 weeks. Store; frozen at -20[o]C for longer periods of time. Avoid multiple freeze-thaw cycles.
- Hersteller:
- Abeomics
- Typ:
- Proteins, Peptides, Small Molecules & Other Biomolecules:Recombinant Proteins
- Datenblatt des Herstellers:1.jpg