Recombinant Human Lipopolysaccarid Binding Protein
Produktgrößen
5 µg
£686,00
32-4098-5UG
Über dieses Produkt
- SKU:
- 32-4098
- Zusätzliche Namen:
- Lipopolysaccharide-binding protein||LBP||MGC22233.
- Weitere Details:
- Source : Chinese Hamster Ovarian Cells (CHO). The Lipopolysaccharide Binding Protein is produced from human LBP transfected CHO-cells in serum free medium. Before transfection the complete human LBP-cDNA was amplified by PCR and cloned into expression vector p-POL-DHFR.The recombinant Human LBP was purified by his-tag with metal affinity purification with Talon and controlled by SDS page.Attention: His-tag has no protease site and can not be split off. Lipopolysaccharides (LPS) are a type of glycolipids on the outer cell wall of Gram-negative bacteria. Lipopolysaccharide binding protein (aka LBP) is a plasma protein which facilitates the diffusion of bacterial LPS (endotoxin). LBP is involved in the acute-phase immunologic response to gram-negative bacterial infections. In cooperation with bactericidal permeability-increasing protein (BPI); LBP binds LPS and interacts with the CD14 receptor; most likely playing a role in regulating LPS-dependent monocyte responses. LBP belongs to a family of structurally and functionally related proteins; including BPI; plasma cholesteryl ester transfer protein (CETP); and phospholipid transfer protein (PLTP). The LBP gene is found on chromosome 20; directly downstream of the BPI gene. LBP catalyzes the transfer of LPS monomers from LPS aggregates to HDL particles; to phospholipid bilayers; and to a binding site on soluble CD14 (sCD14). sCD14 is capable of speeding up the transfer by receiving an LPS monomer from an LPS aggregate; and then yielding it to an HDL particle; therefore acting as a soluble 'shuttle' for an insoluble lipid.
- Versandbedingungen:
- Blue Ice
- Lagerbedingungen:
- Lyophilized LBP Human Recombinant although stable at room temperature for 3 weeks; should be stored desiccated below -18[o]C. Upon reconstitution LBP should be stored at 4[o]C between 2-7 days and for future use below -18[o]C.Please prevent freeze-thaw cycles.
- Hersteller:
- Abeomics
- Typ:
- Proteins, Peptides, Small Molecules & Other Biomolecules
- Datenblatt des Herstellers:1.jpg