ICAM1 HEK Recombinant Protein
Produktgrößen
50 µg
£528,00
32-4001-50UG
Über dieses Produkt
- SKU:
- 32-4001
- Zusätzliche Namen:
- Intercellular adhesion molecule 1||ICAM-1||Major group rhinovirus receptor||CD54 antigen||ICAM1||BB2||CD54||P3.58.
- Weitere Details:
- Source : HEK293 cells. ICAM1 Human Recombinant produced by mammalian expression system in human cells is a single polypeptide chain containing 461 amino acids (28-480). ICAM1 is fused to an 8 amino acid His-tag at C-terminus & purified by proprietary chromatographic techniques. ICAM-1 also called CD54 is a single chain membrane glycoprotein expressed on the surface of a variety of non-haematopoietic and haematopoietic cell types and has roles in signal transduction; cell signaling and lymphocyte adhesion. ICAM1 binds to integrins such as CD11a / CD18; or CD11b / CD18. ICAM1 is also used by Rhinovirus as a receptor. ICAM-1 is an intercellular adhesion molecule constantly present in low concentrations in the membranes of leukocytes and endothelial cells. When stimulated by cytokine the concentrations significantly increase. ICAM-1 can be stimulated by interleukin-1 (IL-1) and tumor necrosis factor alpha (TNFA) and is expressed by the vascular endothelium; macrophages and lymphocytes. ICAM-1 is a ligand for LFA-1 which is a receptor found on leukocytes. Upon activation; leukocytes bind to endothelial cells via ICAM-1/LFA-1 and then transmigrate into tissues.ICAM-1 is implicated in subarachnoid hemorrhage (SAH). Levels of ICAM-1 are shown to be notably elevated in patients with SAH. Soluble ICAM-1 is detectable in the plasma and is elevated in patients with various inflammatory conditions.
- Aufreinigung:
- Greater than 95% as determined by SDS-PAGE.
- Versandbedingungen:
- Blue Ice
- Lagerbedingungen:
- Lyophilized ICAM1 although stable at room temperature for 3 weeks; should be stored desiccated below -18[o]C. Upon reconstitution ICAM1 should be stored at 4[o]C between 2-7 days and for future use below -18[o]C. Please prevent freeze-thaw cycles.
- Hersteller:
- Abeomics
- Typ:
- Proteins, Peptides, Small Molecules & Other Biomolecules
- Datenblatt des Herstellers:1.jpg