HMGB1 Recombinant Protein
Produktgrößen
50 µg
£528,00
32-3972-50UG
Über dieses Produkt
- SKU:
- 32-3972
- Zusätzliche Namen:
- HMG1||HMG3||SBP-1||Amphoterin||HMGB1||High-Mobility Group Box 1.
- Weitere Details:
- Source : Escherichia Coli. HMG1 Human Recombinant fused with 6X His tag produced in E.Coli is a single; non-glycosylated; polypeptide chain containing 223 amino acids and having a molecular mass of 26 kDa.The HMGB-1 is purified by proprietary chromatographic techniques. High-mobility group box 1 protein (HMGB1); previously known as HMG-1 or amphoterin; is a member of the high mobility group box family of non-histone chromosomal proteins. Human HMGB1 is expressed as a 30 kDa; 215 amino acid (aa) single chain polypeptide containing three domains: two N-terminal globular; 70 aa positively charged DNA-binding domains (HMG boxes A and B); and a negatively charged 30 aa C-terminal region that contains only Asp and Glu.4; 5 Residues 27 - 43 and 178 - 184 contain a NLS. Posttranslational modifications of the molecule have been reported; with acetylation occurring on as many as 17 lysine residues. HMGB1 is expressed at high levels in almost all cells. It was originally discovered as a nuclear protein that could bend DNA. Such bending stabilizes nucleosome formation and regulates the expression of select genes upon recruitment by DNA binding proteins.
- Aufreinigung:
- Greater than 95.0% as determined by:(a) Analysis by RP-HPLC.(b) Analysis by SDS-PAGE.
- Versandbedingungen:
- Blue Ice
- Lagerbedingungen:
- Lyophilized HMGB1 although stable at room temperature for 3 weeks; should be stored desiccated below -18[o]C. Upon reconstitution HMGB1 should be stored at 4[o]C between 2-7 days and for future use below -18[o]C.For long term storage it is recommended to add a carrier protein (0.1% HSA or BSA).Please prevent freeze-thaw cycles.
- Hersteller:
- Abeomics
- Typ:
- Proteins, Peptides, Small Molecules & Other Biomolecules
- Datenblatt des Herstellers:1.jpg