Haptoglobin Recombinant Protein
Produktgrößen
20 µg
£528,00
32-3932-20UG
Über dieses Produkt
- SKU:
- 32-3932
- Zusätzliche Namen:
- Haptoglobin||HP||BP||HPA1S||MGC111141||HP2-ALPHA-2.
- Weitere Details:
- Source : Escherichia Coli. Haptoglobin Human Recombinant produced in E.Coli is a single; non-glycosylated; polypeptide chain containing (aa. 145-405) fusion protein with His tag and having a total Mw of 33 kDa (4 kDa His-tag). Haptoglobin is a glycoprotein which is synthesized in the liver and circulates in the blood. Haptoglobin is produced typically by hepatocytes but also by other tissues: e.g. skin; lung; and kidney. It is a positive acute phase protein that binds free hemoglobin and removes it from the circulation to prevent kidney injury; and iron loss following hemolysis. The haptoglobin-hemoglobin complex is subsequently removed by the reticuloendothelial system (generally the spleen). As the reticuloendothelial system removes the haptoglobin-hemoglobin complex from the body; haptoglobin levels are reduced in hemolytic anaemias. In the course of binding hemoglobin; haptoglobin sequesters the iron inside hemoglobin; preventing iron-utilizing bacteria from benefitting from hemolysis. Haptoglobin consists of two A- and two B-chains; connected by disulfide bonds. Three major haptoglobin phenotypes are known to exist (Hp 1-1; Hp 2-1; and Hp 2-2). Hp 1-1 is biologically the most effective in binding free hemoglobin and suppressing inflammatory responses associated with free hemoglobin. Hp 2-2 is biologically the least active; and Hp 2-1 is moderately active. Haptoglobin's molecular mass ranges from 8-200 kDa.Reduced levels can be seen in haemolysis and impaired liver function. High levels are a marker for acute or chronic inflammation. Ahaptoglobinemia or hypohaptoglobinemia are caused by mutations in the haptoglobin gene and/or its regulatory regions. Haptoglobin is also linked to diabetic nephropathy; the incidence of coronary artery disease in type 1 diabetes; Crohn's disease; inflammatory disease behavior; primary sclerosing cholangitis; susceptibility to idiopathic Parkinson's disease; and a reduced incidence of Plasmodium falciparum malaria.
- Aufreinigung:
- Greater than 90.0% as determined by SDS-PAGE and HPLC.
- Versandbedingungen:
- Blue Ice
- Lagerbedingungen:
- Lyophilized Haptoglobin although stable at room temperature for 3 weeks; should be stored desiccated below -18[o]C. Upon reconstitution Haptoglobin should be stored at 4[o]C between 2-7 days and for future use below -18[o]C.For long term storage it is recommended to add a carrier protein (0.1% HSA or BSA).Please prevent freeze-thaw cycles.
- Hersteller:
- Abeomics
- Typ:
- Proteins, Peptides, Small Molecules & Other Biomolecules
- Datenblatt des Herstellers:1.jpg