FCGR3A Recombinant Protein
Produktgrößen
20 µg
£528,00
32-3822-20UG
Über dieses Produkt
- SKU:
- 32-3822
- Zusätzliche Namen:
- Low affinity immunoglobulin gamma Fc region receptor III-A||CD16a antigen||Fc-gamma||RIII-alpha||Fc-gamma RIII||Fc-gamma RIIIa||FcRIII||FcRIIIa||FcR-10||IgG Fc receptor III-2||CD16a||FCGR3A||FCG3||FCGR3||IGFR3||CD16||FCGRIII.
- Weitere Details:
- Source : E.coli. FCGR3A Human Recombinant produced in E.Coli is a single; non-glycosylated polypeptide chain containing 228 amino acids (18-208 a.a) and having a molecular mass of 26kDa.FCGR3A is fused to a 37 amino acid His-tag at N-terminus & purified by proprietary chromatographic techniques. Low affinity immunoglobulin gamma Fc region receptor III-A (FCGR3A) is a receptor for the Fc portion of immunoglobulin G; and is involved in the elimination of antigen-antibody complexes from the circulation; as well as other antibody-dependent responses. FCGR3A needs to associate with the gamma subunit of Fc epsilon. The FCGR3A receptor is expressed on natural killer (NK) cells as an integral membrane glycoprotein anchored through a transmembrane peptide; while FCGR3B is expressed on polymorphonuclear neutrophils (PMN) where the receptor is anchored through a phosphatidylinositol (PI) linkage. In addition; FCGR3A is expressed on macrophages; subpopulation of T-cells; immature thymocytes and placental trophoblasts. FCGR3A mediates antibody-dependent cellular cytotoxicity (ADCC) and other antibody-dependent responses; such as phagocytosis. FCGR3A gene mutations are linked with susceptibility to recurrent viral infections; susceptibility to systemic lupus erythematosus; and alloimmune neonatal neutropenia.
- Aufreinigung:
- Greater than 90% as determined by SDS-PAGE.
- Versandbedingungen:
- Blue Ice
- Lagerbedingungen:
- Store at 4[o]C if entire vial will be used within 2-4 weeks. Store; frozen at -20[o]C for longer periods of time. For long term storage it is recommended to add a carrier protein (0.1% HSA or BSA).Avoid multiple freeze-thaw cycles.
- Hersteller:
- Abeomics
- Typ:
- Proteins, Peptides, Small Molecules & Other Biomolecules
- Datenblatt des Herstellers:1.jpg