Coagulation factor IX Native Protein
Produktgrößen
100 µg
£1181,00
32-3784-100UG
Über dieses Produkt
- SKU:
- 32-3784
- Zusätzliche Namen:
- Coagulation factor IX||EC 3.4.21.22||Christmas factor||Plasma thromboplastin component||PTC||F9||FIX||HEMB||MGC129641||MGC129642||GLA domain||Factor IX.
- Weitere Details:
- Source : Human Plasma. Human Factor-IX produced from fresh frozen human plasma is a glycosylated polypeptide chain having a molecular mass of 56 kDa. Human Factor IX also called Christmas-Factor is a glycoprotein; which is synthesized in the liver and belongs to the serine proteases system and is part of the S1 peptidase family.Lack of Factor-IX causes Hemophilia-B meaning Christmas Disease. Factor-IX has a N-terminus region which contains 12xGla residues which asist the calcium dpendant binding of Factor-IX to the phospholipid surface. Factor-IX is activated by either factor XIa or the factor VIIa/tissue factor/phospholipid complex. Cleavage yields the intermediate IXa; which is subsequently converted to the fully active form IXab.Factor-IX binds initially to exosites on the factor XIa heavy chain; followed by interaction at the active site with subsequent bond cleavage. Coagulation factor IX is activated by interaction with the erythrocyte membrane; causing intrinsic coagulation. Chaperones & lectins act simultaniously to guarantee the proper folding of Factor-IX and the retention of mutant molecules. Human Factor IX; activated by either the Contact or Tissue Factor Pathway; is responsible for the activation of Factor X to Xa.
- Aufreinigung:
- Greater than 95.0% as determined by SDS-PAGE.
- Versandbedingungen:
- Blue Ice
- Lagerbedingungen:
- Lyophilized Factor-IX although stable at room temperature for 3 weeks; should be stored desiccated below -18[o]C. Upon reconstitution Factor-IX should be stored at 4[o]C between 2-7 days and for future use below -18[o]C.Please prevent freeze-thaw cycles.
- Hersteller:
- Abeomics
- Typ:
- Proteins, Peptides, Small Molecules & Other Biomolecules
- Datenblatt des Herstellers:1.jpg