F3 Recombinant Protein
Produktgrößen
10 µg
£528,00
32-3781-10UG
Über dieses Produkt
- SKU:
- 32-3781
- Zusätzliche Namen:
- Tissue factor||Coagulation factor III||Thromboplastin||CD142||TF||F3||TFA.
- Weitere Details:
- Source : Escherichia Coli. Tissue factor Human Recombinant produced in E.Coli is single; a non-glycosylated; Polypeptide chain containing 219 amino acids of the extracellular domain (33-251) having a molecular mass of 29.39 kDa and fused with a 4.5kDa amino-terminal hexahistidine tag. The Tissue factor is purified by proprietary chromatographic techniques. Tissue factor is well-known as the main cellular initiator of blood coagulation. The Tissue factor gene encodes coagulation factor III which is a cell surface glycoprotein that enables cells to initiate the blood coagulation cascades; and functions as the high-affinity receptor for the coagulation factor VII. Following vessel injury; the Tissue Factor and Factor VIIa complex activates the coagulation protease cascade; which leads to fibrin deposition and activation of platelets. The ensuing complex presents a catalytic event; which is responsible for initiation of the coagulation protease cascades by specific limited proteolysis. Therefore; Tissue factor has a role in normal hemostasis by initiating the cell-surface assembly and propagation of the coagulation protease cascade. Tissue Factor can also be stimulated by the inflammatory mediators interleukin 1 and TNF; as well as by endotoxin; to appear on monocytes and vascular endothelial cells as a component of cellular immune response.Tissue factor is the only one in the coagulation pathway for which a congenital deficiency has not been described. Certain levels of Tissue Factor are essential for the maintained viability and growth of endothelium and Tissue Factor-expressing tumor cells. Additionally; abnormal Tissue Factor expression inside the vasculature initiates life threatening thrombosis in various diseases; for example sepsis; atherosclerosis; and cancer. Alternative spliced Tissue Factor expression advances tumor growth; and is linked to increased tumor cell proliferation and angiogenesis in pancreatic cancer.
- Aufreinigung:
- Greater than 95.0% as determined by SDS-PAGE.
- Versandbedingungen:
- Blue Ice
- Lagerbedingungen:
- Store at 4[o]C if entire vial will be used within 2-4 weeks. Store; frozen at -20[o]C for longer periods of time. Please avoid freeze thaw cycles.
- Hersteller:
- Abeomics
- Typ:
- Proteins, Peptides, Small Molecules & Other Biomolecules
- Datenblatt des Herstellers:1.jpg