ERCC1 Recombinant Protein
Produktgrößen
10 µg
£528,00
32-3758-10UG
Über dieses Produkt
- SKU:
- 32-3758
- Zusätzliche Namen:
- Excision Repair Cross-complementing rodent repair deficiency complementation group 1 (includes overlapping antisense sequence)||RAD10||COFS4||UV20||DNA excision repair protein ERCC-1.
- Weitere Details:
- Source : E.coli. ERCC1 Human Recombinant produced in E. coli is a single polypeptide chain containing 297 amino acids (1-273) and having a molecular mass of 32.5kDa.ERCC1 is fused to a 24 amino acid His-tag at N-terminus & purified by proprietary chromatographic techniques. ERCC1 polypeptide is essential for nucleotide excision repair (NER) of damaged DNA and is homologous to Saccharomyces cerevisiae RAD10; which takes part in repair and mitotic intra-chromosomal recombination. NER mechanism includes dual incisions on both sides of the damage catalyzed by two nucleases. In mammalian cells XPG cleaves 3' of the DNA lesion while the ERCC1-XPF complex makes the 5' incision. Raised levels of ERCC1 were also found in cisplatin-resistant cells.
- Aufreinigung:
- Greater than 90% as determined by SDS-PAGE.
- Versandbedingungen:
- Blue Ice
- Lagerbedingungen:
- Store at 4[o]C if entire vial will be used within 2-4 weeks. Store; frozen at -20[o]C for longer periods of time. For long term storage it is recommended to add a carrier protein (0.1% HSA or BSA).Avoid multiple freeze-thaw cycles.
- Hersteller:
- Abeomics
- Typ:
- Proteins, Peptides, Small Molecules & Other Biomolecules
- Datenblatt des Herstellers:1.jpg