Cyclosporin-A
Produktgrößen
4 grams
£528,00
32-3644-4GRAMS
Über dieses Produkt
- SKU:
- 32-3644
- Weitere Details:
- Source : Beauveria Nlyea. Cyclosporin is a cyclic polypeptide immunosuppressant agent consisting of 11 amino acids and having a molecular weight of 1202.64. It is produced as a metabolite by the fungus species Beauveria nlyea. Chemically; cyclosporin is designated as [R-[R*;R*-(E)]]-cyclic(L-alanyl-D- alanyl-N-methyl-L-leucyl-N-methyl-L-leucyl-N-methyl-L-valyl-3-hydroxy-N; 4-dimethyl-L-2-amino-6-octenoyl-L-a-amino-butyryl- N-methylglycyl-N- methyl-L-leucyl-L-valyl-N-methyl-L-leucyl). Molecular Formula: C62H111N11O12. Cyclosporin A is a noncytotoxic; natural; 11 amino acid cyclic peptide used clinically as an immunosuppressant for the treatment of autoimmune and inflammatory disorders and to prevent organ rejection after transplantation. Cyclosporin acts chiefly by inhibiting T lymphocyte function; which is vital for the propagation of inflammation. Cyclosporin A does not suppress the activity of other hematopoietic cells; does not cause bone marrow suppression and has a rapid onset of action as opposed to other immunosuppressive agents. Nevertheless; Cyclosporin A -induced nephrotoxicity remains an important clinical problem; and oxidative stress has been implicated as a potential responsible mechanism.
- Aufreinigung:
- Greater than 99.0% as determined by RP-HPLC.
- Versandbedingungen:
- Blue Ice
- Lagerbedingungen:
- Lyophilized Cyclosporin A although stable at room temperature for 3 weeks; should be stored desiccated below -18[o]C. Upon reconstitution Cyclosporin A should be stored at 4[o]C between 2-7 days and for future use below -18[o]C.Please prevent freeze-thaw cycles.
- Hersteller:
- Abeomics
- Typ:
- Proteins, Peptides, Small Molecules & Other Biomolecules
- Datenblatt des Herstellers:1.jpg