CDC37 Recombinant Protein
Produktgrößen
25 µg
£528,00
32-3490-25UG
Über dieses Produkt
- SKU:
- 32-3490
- Zusätzliche Namen:
- P50CDC37||CDC-37||CDC37||Hsp90 co-chaperone Cdc37||Hsp90 chaperone protein kinase-targeting subunit||CDC37A||Cell Division Cycle 37.
- Weitere Details:
- Source : Escherichia Coli. CDC37 Human Recombinant produced in E.Coli is a single; non-glycosylated polypeptide chain containing 378 amino acids and having a molecular mass of 44.4 kDa. CDC37 is an essential protein in Saccharomyces cerevisiae and is a molecular chaperone with precise function in cell signal transduction. CDC37 forms a complex/associates with Hsp90 molecular chaperone as one of several auxiliary proteins that are collectively referred to as Hsp90 co-chaperones. CDC37 also forms complex with a number of protein kinases such as CDK4; CDK6; SRC; RAF-1; MOK; as well as eIF2 alpha kinases. CDC34 is involved in directing Hsp90 to its target kinases. CDC37 up-regulation is a common early event in some localized human cancers. CDC37 is necessary for maintaining prostate tumor cell growth and represents a novel target in the exploration for multitargeted therapies. CDC37 plays a role in regulating Hsp90 ATPase activity. CDC37 binds to Akt and HSP90 in the signal transduction pathway in human tumor cells. Tnf-induced recruitment and activation of the IKK complex require Cdc37 and Hsp90. CDC37 and heat shock protein 90 bind specifically to the kinase domain of LKB1.
- Aufreinigung:
- Greater than 95.0% as determined by SDS-PAGE.
- Versandbedingungen:
- Blue Ice
- Lagerbedingungen:
- Store at 4[o]C if entire vial will be used within 2-4 weeks. Store; frozen at -20[o]C for longer periods of time. For long term storage it is recommended to add a carrier protein (0.1% HSA or BSA).Avoid multiple freeze-thaw cycles.
- Hersteller:
- Abeomics
- Typ:
- Proteins, Peptides, Small Molecules & Other Biomolecules
- Datenblatt des Herstellers:1.jpg