mC5a Recombinant Protein
Produktgrößen
10 µg
£528,00
32-3386-10UG
Über dieses Produkt
- SKU:
- 32-3386
- Zusätzliche Namen:
- Complement C5||Hemolytic complement||C5||Hc||He||C5a.
- Weitere Details:
- Source : Escherichia Coli. C5a Mouse Recombinant produced in E.Coli is a single; non-glycosylated; Polypeptide chain containing 77 amino acids and having a molecular mass of 9kDa.The Mouse C5a is purified by proprietary chromatographic techniques. Mouse Complement 5a (C5a) is a glycoprotein which is a member of a family of structurally and functionally related proteins known as anaphylatoxins. C5a is a 77 a.a. peptide created by the C5a convertase proteolytic cleavage of C5 chain in the classical and alternative complement pathway (C4b2a3b; C3bBb3b). The mouse C5a has four helices and three intrachain disulfide bonds which form a triple loop structure. C5a functions through G-protein coupled receptor (GPCR) (C5aR/CD88). C5a is a effective chemoattractant and anaphylatoxin which functions on all classes of leukocytes and on many other cell types including endothelial; smooth muscle; kidney; liver; and neural cells. Mouse C5a also mediates IL-8 release from bronchial epithelial cells. Furthermore; it triggers an oxidative surge in macrophages and neutrophils; causing the release of histamine in basophils and mast cells. The C5a anaphylatoxin activity on hepatocytes results indirectly from interaction with nonparenchymal cell via prostanoid secretion.
- Aufreinigung:
- Greater than 95.0% as determined by:(a) Analysis by RP-HPLC.(b) Analysis by SDS-PAGE.
- Versandbedingungen:
- Blue Ice
- Lagerbedingungen:
- Lyophilized Mouse C5a although stable at room temperature for 3 weeks; should be stored desiccated below -18[o]C. Upon reconstitution Mouse C5a should be stored at 4[o]C between 2-7 days and for future use below -18[o]C.Please prevent freeze-thaw cycles.
- Hersteller:
- Abeomics
- Typ:
- Proteins, Peptides, Small Molecules & Other Biomolecules
- Datenblatt des Herstellers:1.jpg