mBID Recombinant Protein
Produktgrößen
10 µg
£528,00
32-3331-10UG
Über dieses Produkt
- SKU:
- 32-3331
- Zusätzliche Namen:
- BH3-interacting domain death agonist||p22 BID||BID||FP497||MGC15319||MGC42355.
- Weitere Details:
- Source : Escherichia Coli. BID Mouse Recombinant produced in E.Coli is a single; non-glycosylated polypeptide chain containing 1-195 amino acids and having a molecular mass of 22 kDa. BID is a pro-apoptotic Bcl-2 protein having only the BH3 domain. In reaction to apoptotic signaling; BID interacts with another Bcl-2 family of cell death regulators; called Bax; they form a heterodimer resulting to the insertion of Bax into the outer mitochondrial membrane. Bax induces the opening of the mitochondrial voltage-dependent anion channel which lead to the release of cytochrome c and other pro-apoptotic factors from the mitochondria resulting in activation of caspases. BID is a mediator of mitochondrial damage induced by caspase-8 (CASP8). CASP8 cleaves BID; and the COOH-terminal part translocates to mitochondria where it triggers cytochrome c release. The major proteolytic product p15 BID releasea cytochrome c. Isoform 1; Isoform 2 and Isoform 4 induce ice-like proteases and apoptosis while Isoform 3 does not induce apoptosis.
- Aufreinigung:
- Greater than 95.0% as determined by(a) Analysis by RP-HPLC.(b) Analysis by SDS-PAGE.
- Versandbedingungen:
- Blue Ice
- Lagerbedingungen:
- BID although stable at 15[o]C for 1 week; should be stored desiccated below -18[o]C. For long term storage it is recommended to add a carrier protein (0.1% HSA or BSA).Please prevent freeze-thaw cycles.
- Hersteller:
- Abeomics
- Typ:
- Proteins, Peptides, Small Molecules & Other Biomolecules
- Datenblatt des Herstellers:1.jpg