B2M Recombinant Protein
Produktgrößen
50 µg
£528,00
32-3281-50UG
Über dieses Produkt
- SKU:
- 32-3281
- Zusätzliche Namen:
- Beta-2-microglobulin||B2M.
- Weitere Details:
- Source : Escherichia Coli. B2 Microglobulin Human Recombinant produced in E.Coli is a non-glycosylated polypeptide chain having a molecular mass of 11.76 kDa.The B2M is purified by proprietary chromatographic techniques. 2 microglobulin is an 11 kDa protein associated with the outer membrane of many cells including lymphocytes. It is the small subunit of the MHC class I molecule. Association with beta 2-microglobulin is generally required for the transport of class I heavy chains from the endoplasmic reticulum to the cell surface. 2 microglobulin associates with class I-like molecules such as CD1 and Qa as well as with the alpha chain of MHC class I molecules. Very limited amounts of MHC class I molecules can be found on the surface in the absence of 2 microglobulin. CD8 T cells cannot develop in the absence of MHC class I.Beta 2-microglobulin is present in small amounts in serum; csf; and urine of normal people; and to a much greater degree in the urine and plasma of patients with tubular proteinaemia; renal failure; or kidney transplants. Human Beta 2 microglobulin levels can rise either because its rate of synthesis has increased (e.g. in AIDS; malignant monoclonal plasma cell dyscrasia; solid tumors and autoimmune disease) or because of impaired renal filtration (e.g. due to renal insufficiency; graft rejection or nephrotoxicity induced by post-transplantation immunosuppressive therapy). Beta-2 microglobulin levels might also be elevated in multiple myeloma and lymphoma cases. Dialysis-related amyloidosis develops after a long-term hemodialysis; it can aggregate into amyloid fibers that deposit in joint spaces.
- Aufreinigung:
- Greater than 95.0% as determined by(a) Analysis by RP-HPLC.(b) Analysis by SDS-PAGE.
- Versandbedingungen:
- Blue Ice
- Lagerbedingungen:
- Lyophilized B2M although stable at room temperature for 3 weeks; should be stored desiccated below -18[o]C. Upon reconstitution B2M should be stored at 4[o]C between 2-7 days and for future use below -18[o]C.For long term storage it is recommended to add a carrier protein (0.1% HSA or BSA).Please prevent freeze-thaw cycles.
- Hersteller:
- Abeomics
- Typ:
- Proteins, Peptides, Small Molecules & Other Biomolecules
- Datenblatt des Herstellers:1.jpg