AHSG Native Protein
Produktgrößen
50 µg
£528,00
32-3169-50UG
Über dieses Produkt
- SKU:
- 32-3169
- Zusätzliche Namen:
- Alpha-2-HS-glycoprotein||Fetuin-A||Alpha-2-Z-globulin||Ba-alpha-2-glycoprotein||AHSG||FETUA||AHS||A2HS||HSGA||PRO2743.
- Weitere Details:
- Source : Purified from the human plasma. The human Alpha-2-HS-Glycoprotein was purified from the human plasma. Fetuin is a liver-produced negative acute phase protein composed of two subunits; the A and B chains.Fetuin homologs have been identified in several species including rat; sheep; pig; rabbit; guinea pig; cattle; mouse and human. Multiple physiological roles for these homologs have been suggested; including ability to bind to hydroxyapatite crystals and to specifically inhibit the tyrosine kinase (TK) activity of the insulin receptor (IR).Fetuin-A (alpha2-Heremans-Schmid glycoprotein; AHSG) is an important circulating inhibitor of calcification in vivo; and is downregulated during the acute-phase response.Sera from patients on long-term dialysis with low AHSG concentrations showed impaired ex-vivo capacity to inhibit CaxPO4 precipitation.Fetuin may influence the resolution of inflammation by modulating the phagocytosis of apoptotic cells by macrophages.ASHG blocks TGF-beta-dependent signaling in osteoblastic cells; and mice lacking ASHG display growth plate defects; increased bone formation with age; and enhanced cytokine-dependent osteogenesis.
- Aufreinigung:
- Greater than 95% as determined by SDS-PAGE.
- Versandbedingungen:
- Blue Ice
- Lagerbedingungen:
- Store the lyophilized protein at -20[o]C. Aliquot the product after reconstitution to avoid repeated freezing/thawing cycles. Reconstituted protein can be stored at 4[o]C for a limited period of time; it does not show any change after two weeks at 4[o]C.
- Hersteller:
- Abeomics
- Typ:
- Proteins, Peptides, Small Molecules & Other Biomolecules
- Datenblatt des Herstellers:1.jpg