Alpha-2 Macroglobulin Native Protein
Produktgrößen
1 mg
£705,00
32-3149-1MG
Über dieses Produkt
- SKU:
- 32-3149
- Zusätzliche Namen:
- Alpha-2-macroglobulin||Alpha-2-M||A2M||CPAMD5||FWP007||S863-7||alpha 2M||DKFZp779B086.
- Weitere Details:
- Source : Human Plasma. Human Alpha-2 Macroglobulin is a tetrameric glycoprotein; produced in Human plasma and having a molecular mass of 725 kDa. Alpha-2 Macroglobulin is a serine proteases inhibitor; which inhibits coagulation by inactivating thrombin and Kallikrein; it inhibits fibrinolysis by inactivating plasmin and involved in insulin transport. Alpha-2-Macroglobulin is a large plasma protein; which is produced by the liver; it's composed of 4 identical subunits bound together by -S-S- bonds. A2M is able to inactivate many kinds of proteinases (including serine-; cysteine-; aspartic- and metalloproteinases). A2M has a 35 amino acid 'bait' region in its structure. Proteinases bind and cleave the 'bait' region become bound to A2M. Macrophage receptors recognize the proteinase-A2M complex and clear it from the system. A2M binds to and removes MMP-2 and MMP-9 (active forms of the gelatinase) from the circulation using scavenger receptors on the phagocytes. The levels of Alpha-2-macroglobulin are increased in nephrotic syndrome which is a condition where the kidneys start to leak out some of the smaller blood proteins. Due to its large size; A2-macroglobulin is retained in the bloodstream. Increased production of all proteins causes A2-macroglobulin concentration to increase. Chronic renal failure might lead to amyloid by alpha-2-macroglobulin. A2M is raised in cirrhosis; pregnancy and diabetes.
- Aufreinigung:
- Greater than 96.0%.
- Versandbedingungen:
- Blue Ice
- Lagerbedingungen:
- Human Alpha-2 Macroglobulin although stable at room temperature for 3 weeks; should be stored between 2-8[o]C. Do not freeze!
- Hersteller:
- Abeomics
- Typ:
- Biomaterials:Blood Products
- Datenblatt des Herstellers:1.jpg