TIE-2 Fc Recombinant Protein
Produktgrößen
10 µg
£528,00
32-3122-10UG
Über dieses Produkt
- SKU:
- 32-3122
- Zusätzliche Namen:
- Angiopoietin-1 receptor precursor||Tyrosine-protein kinase receptor TIE-2||hTIE2||Tyrosine-protein kinase receptor TEK||p140 TEK||Tunica interna endothelial cell kinase||CD202b||VMCM||VMCM1||TIE2.
- Weitere Details:
- Source : Insect Cells. Soluble TEK Human Recombinant fused with the Fc part of human IgG1 produced in baculovirus is a monomeric; glycosylated; polypeptide containing 730 amino acids and having a total molecular mass of 250 kDa. Human TIE-2/Fc monomer has a calculated molecular mass of approximately 125 kDa. As a result of glycosylation; the recombinant protein migrates as an approximately 140 kDa protein in SDS-PAGE under reducing conditions.The TEK Fc Chimera is purified by proprietary chromatographic techniques. TIE-1 (tyrosine kinase with Ig and EGF homology domains 1) and TIE-2/Tek comprise a receptor tyrosine kinase (RTK) subfamily with unique structural characteristics: two immunoglobulin-like domains flanking three epidermal growth factor (EGF)-like domains and followed by three fibronectin type III-like repeats in the extracellular region and a split tyrosine kinase domain in the cytoplasmic region. These receptors are expressed primarily on endothelial and hematopoietic progenitor cells and play critical roles in angiogenesis; vasculogenesis and hematopoiesis. Human TIE-1 cDNA encodes a 1122 amino acid (aa) residue precursor protein with an 18 residue putative signal peptide; a 726 residue extracellular domain and a 353 residue cytoplasmic domain. Two ligands; angiopoietin-1 (Ang1) and angiopoietin-2 (Ang2); which bind TIE-2 with high-affinity have been identified. Ang2 has been reported to act as an antagonist for Ang1. Mice engineered to overexpress Ang2 or to lack Ang1 or Tie-1 display similar angiogenic defects.
- Aufreinigung:
- Greater than 90.0% as determined by:(a) Analysis by RP-HPLC.(b) Analysis by SDS-PAGE.
- Versandbedingungen:
- Blue Ice
- Lagerbedingungen:
- Lyophilized sTIE-2 although stable at room temperature for 3 weeks; should be stored desiccated below -18[o]C. Upon reconstitution TEK should be stored at 4[o]C between 2-7 days and for future use below -18[o]C.For long term storage it is recommended to add a carrier protein (0.1% HSA or BSA).Please prevent freeze-thaw cycles.
- Hersteller:
- Abeomics
- Typ:
- Proteins, Peptides, Small Molecules & Other Biomolecules
- Datenblatt des Herstellers:1.jpg