PTPN6 Recombinant Protein
Produktgrößen
20 µg
£528,00
32-3108-20UG
Über dieses Produkt
- SKU:
- 32-3108
- Zusätzliche Namen:
- Tyrosine-protein phosphatase non-receptor type 6||EC 3.1.3.48||Protein-tyrosine phosphatase 1C||PTP-1C||Hematopoietic cell protein-tyrosine phosphatase||SH-PTP1||Protein-tyrosine phosphatase SHP-1||PTPN6||HCP||HCPH||SHP1||HPTP1C||SHP-1L.
- Weitere Details:
- Source : Escherichia Coli. PTPN6 Human Recombinant produced in E.Coli is a single;non-glycosylated polypeptide chain containing 300 amino acids and having a molecular mass of 34.3 kDa. The protein coding region of the catalytic domain of PTPN6 (amino acids 243-541). The catalytic domain of PTPN6 was overexpressed as insoluble protein aggregates (inclusion bodies). The recombinant PTPN6 protein was purified by FPLC gel-filtration chromatography; after refolding of the isolated inclusion bodies in a redox buffer. Additional amino acid(Met) is attached at N-terminus. PTPN6 is a member of the protein tyrosine phosphatase (PTP) family. PTPs are known to be signaling molecules that regulate a variety of cellular processes including cell growth; differentiation; mitotic cycle; and oncogenic transformation. N-terminal part of this PTP contains two tandem Src homolog (SH2) domains; which act as protein phospho-tyrosine binding domains; and mediate the interaction of this PTP with its substrates. This PTP is expressed primarily in hematopoietic cells; and functions as an important regulator of multiple signaling pathways in hematopoietic cells. This PTP has been shown to interact with; and dephosphorylate a wide spectrum of phospho-proteins involved in hematopoietic cell signaling. Multiple alternatively spliced variants of this gene; which encode distinct isoforms; have been reported.
- Aufreinigung:
- Greater than 95.0% as determined by SDS-PAGE.
- Versandbedingungen:
- Blue Ice
- Lagerbedingungen:
- Store at 4[o]C if entire vial will be used within 2-4 weeks. Store; frozen at -20[o]C for longer periods of time. For long term storage it is recommended to add a carrier protein (0.1% HSA or BSA). Avoid multiple freeze-thaw cycles.
- Hersteller:
- Abeomics
- Typ:
- Proteins, Peptides, Small Molecules & Other Biomolecules
- Datenblatt des Herstellers:1.jpg