PKACa2/RIa2 Recombinant Protein
Produktgrößen
3 µg
£528,00
32-3083-3UG
Über dieses Produkt
- SKU:
- 32-3083
- Zusätzliche Namen:
- Protein Kinase A holoenzyme type I alpha||PKACa2- RIa2.
- Weitere Details:
- Source : Escherichia Coli. Inactive holoenzyme consisting of one dimeric regulatory subunit type I alpha and two monomeric catalytic subunits (cAMP-free). Protein Kinase A Recombinant is purified by proprietary chromatographic techniques. The protein kinase A holoenzyme is a heterotetramer composed of two types of subunits: Catalytic and Regulatory. The Catalyticsubunit contains the enzyme's active site. It also contains a domain that binds ATP and a domain that binds the regulatory subunit. The Regulatory subunit consists oftwo molecules which bind one another in an anti-parallel orientation to form a homodimer; for type I subunits- this binding is covalent via disulfide bonds. This subunit also has has two domains that bind cyclic AMP; a domain that interacts with a catalytic subunit; and an 'auto-inhibitory' domain that serves as a substrate or pseudosubstrate for the catalytic subunit. Regulatory subunits may also have biologic activity distinct from their role in modulating catalytic subunit activity. Regulatory subunits exist in two major forms; RI and RII; with each form having two subtypes designated alpha and beta. Each of the four isotypes of the regulatory subunit is encoded by a different gene. In addition; three isotypes of the catalytic subunit have been identified (alpha; beta and gamma). The different isotypes tend to have different distributions within cells and among tissues. Type I enzymes inhabit cytoplasmic; soluble fractions of the cell; whereas type II enzymes tend to associate with cellular membranes.
- Aufreinigung:
- Greater than 95.0% as determined by SDS-PAGE.
- Versandbedingungen:
- Blue Ice
- Lagerbedingungen:
- PKA should be stored at 4[o]C if entire vial will be used within 2-4 weeks. For long term storage it is recommended to store at -20[o]C. Avoid multiple freeze-thaw cycles.
- Hersteller:
- Abeomics
- Typ:
- Proteins, Peptides, Small Molecules & Other Biomolecules
- Datenblatt des Herstellers:1.jpg