PI3Kb Recombinant Protein
Produktgrößen
2.5 µg
£631,00
32-3077-2.5UG
Über dieses Produkt
- SKU:
- 32-3077
- Zusätzliche Namen:
- Phosphoinositide 3-kinase beta p110?/p85?||PI3K ?||PI3Kb.
- Weitere Details:
- Source : Sf9 insect cells. Phosphoinositide 3-kinase beta Human Recombinant is a glycosilated protein having a molecular weight as follows: p85 chain 83.5 kDa; p110 chain 124.3 kDa. The PI3Kb isoform can be activated by insulin via the insulin receptor to initiate a cascade of events that control cell growth and metabolism. The activation ofPI3Kb is mediated by the p85 regulatory subunit binding to tyrosine phosphorylated insulin receptor substrate (IRS) proteins (e.g. IRS-1 and IRS-2). It was also shown that PI3Kb is involved in apoptosis in human colon carcinoma cells. Injection of neutralizing antibodies specific to p110b in WiDr;HCT116 and CO 115 adenocarcinoma cells inhibited de novo DNA synthesis.PI3Kb is the major PI3K isoform required for apoptotic cell and Fc-g receptor mediated phagocytosis shown for primary mouse macrophages and the Jurkat human leukemia T cell line.It was shown by several research groups that the catalytic subunit of PI3Kb can be activated by Gbg subunits of G-protein coupled receptors.
- Aufreinigung:
- Greater than 90.0% as determined by SDS Page.
- Versandbedingungen:
- Blue Ice
- Lagerbedingungen:
- PI3Kb although stable at 4[o]C for 1 week; should be stored desiccated below -18[o]C. For long term storage it is recommended to add a carrier protein (0.1% HSA or BSA).Please prevent freeze-thaw cycles.
- Hersteller:
- Abeomics
- Typ:
- Proteins, Peptides, Small Molecules & Other Biomolecules
- Datenblatt des Herstellers:1.jpg