p38a/SAPK2a Recombinant Protein
Produktgrößen
5 µg
£775,00
32-3068-5UG
Über dieses Produkt
- SKU:
- 32-3068
- Zusätzliche Namen:
- Mitogen-activated protein kinase 14||EC 2.7.11.24||Mitogen-activated protein kinase p38 alpha||MAP kinase p38 alpha||Cytokine suppressive anti-inflammatory drug-binding protein||CSAID-binding protein||CSBP||MAX-interacting protein 2||MAP kinase MXI2;
- Weitere Details:
- Source : Escherichia Coli. p38/SAPK2 is a non-glycosilated polypeptide produced by phosphorylation of the purified p38 alpha with MKK6 having a molecular mass of 42.7 kDa. p38a/SAPK2 is a member of the MAP kinase family. MAP kinases act as an integration point for multiple biochemical signals; and are involved in a wide variety of cellular processes such as proliferation; differentiation; transcription regulation and development. This kinase is activated by various environmental stresses and proinflammatory cytokines. The activation requires its phosphorylation by MAP kinase kinases (MKKs); or its autophosphorylation triggered by the interaction of MAP3K7IP1/TAB1 protein with this kinase. The substrates of this kinase include transcription regulator ATF2; MEF2C; and MAX; cell cycle regulator CDC25B; and tumor suppressor p53; which suggest the roles of this kinase in stress related transcription and cell cycle regulation; as well as in genotoxic stress response. Four alternatively spliced transcript variants of this gene encoding distinct isoforms have been reported.
- Aufreinigung:
- Greater than 95% as determined by SDS-PAGE.
- Versandbedingungen:
- Blue Ice
- Lagerbedingungen:
- Store at 4[o]C if entire vial will be used within 2-4 weeks. Store; frozen at -20[o]C for longer periods of time. Avoid multiple freeze-thaw cycles.
- Hersteller:
- Abeomics
- Typ:
- Proteins, Peptides, Small Molecules & Other Biomolecules
- Datenblatt des Herstellers:1.jpg