MAPK3 Active Recombinant Protein
Produktgrößen
10 µg
£1160,00
32-3054-10UG
Über dieses Produkt
- SKU:
- 32-3054
- Zusätzliche Namen:
- Mitogen-activated protein kinase 3||EC 2.7.11.24||Extracellular signal-regulated kinase 1||ERK-1||Insulin-stimulated MAP2 kinase||MAP kinase 1||MAPK 1||p44-ERK1||ERT2||p44-MAPK||Microtubule-associated protein 2 kinase||ERK1||PRKM3||P44ERK1||P44MAPK||
- Weitere Details:
- Source : Escherichia Coli. ERK1/MAPK3 Recombinant is a highly active form produced by phosphorylation of the purified ERK1/MAPK3 in vitro with MEK1 is a non-glycosylated polypeptide having a molecular mass of 43.6 kDa. ERK1/MAPK3 is purified by proprietary chromatographic techniques. Extracellular signal-regulated kinases (ERKs) or classical MAP kinases are widely expressed protein kinaseintracellular signalingmolecules which are involved in functions including the regulation of meiosis; mitosis; and postmitotic functions in differentiated cells. Many different stimuli; including growth factors; cytokines; virusinfection; ligands for heterotrimeric G protein-coupled receptors; transforming agents; and carcinogens; activate the ERK pathway.The term; 'extracellular signal-regulated kinases'; is sometimes used as a synonym for mitogen-activated protein kinase(MAPK); but has more recently been adopted for a specific subset of the mammalianMAPK family. In the MAPK/ERK pathway; Rasactivates c-Raf; followed by MEKand then MAPK1/2 (below). Ras is typically activated by growth hormones through receptor tyrosine kinasesand GRB2/SOS; but may also receive other signals. ERKs are known to activate many transcription factors and some downstream protein kinases. Disruption of the ERK pathway is common in cancers; especially Ras; c-Raf and receptors such as HER2.Mitogen-activated protein kinase 3 (MAPK3) is also known as 'extracellular signal-regulated kinase 1' (ERK1). Transgenic gene knockoutmice lacking MAPK3 are viable and it is thought that MAPK1 can fulfill most MAPK3 functions in most cells. The main exception is in T cells. Mice lacking MAPK3 have reduced T cell development past the CD4+CD8+ stage.
- Aufreinigung:
- Greater than 95% as determined by SDS-PAGE.
- Versandbedingungen:
- Blue Ice
- Lagerbedingungen:
- Store at 4[o]C if entire vial will be used within 2-4 weeks. Store; frozen at -20[o]C for longer periods of time.Avoid multiple freeze-thaw cycles.
- Hersteller:
- Abeomics
- Typ:
- Proteins, Peptides, Small Molecules & Other Biomolecules
- Datenblatt des Herstellers:1.jpg