ILK1 Recombinant Protein
Produktgrößen
10 µg
£528,00
32-3035-10UG
Über dieses Produkt
- SKU:
- 32-3035
- Zusätzliche Namen:
- Integrin-linked protein kinase||ILK-1||ILK-2||59 kDa serine/threonine-protein kinase||p59ILK||ILK||ILK1||ILK2||DKFZp686F1765||P59.
- Weitere Details:
- Source : Escherichia Coli. ILK1 Human Recombinant produced in E.Coli is single; a non-glycosylated; Polypeptide chain containing 452 amino acids fragment (1-452) having a molecular mass of 55.92kDa and fused with a 4.5kDa amino-terminal hexahistidine tag. The ILK1 is purified by proprietary chromatographic techniques. ILK1 (Integrin-linked kinase) is a serine/threonine protein kinase; containing 4 ankyrin-like repeats. ILK1 regulates a number of biological properties which include: anchorage-independent cell cycle progression; tumor cell invasion and apoptosis. ILK1 can also be implicated in mediating cell architecture; adhesion to integrin substrates and anchorage-dependent growth in epithelial cells. Furthermore; ILK1 phosphorylates beta-1 and beta-3 integrin subunit on serine and threonine residues; but also AKT1 and GSK3B.ILK1 interacts with the cytoplasmic domains of integrin 1 and 3 subunits in addition to several adaptors and signaling proteins; it also acts as a proximal receptor kinase regulating integrin-mediated signal transduction. ILK1 is a focal adhesion protein part of the complex ILK-PINCH. This complex is deemed to be one of the convergence points of integrin- and growth factor-signaling pathway. ILK1 is stimulated rapidly but briefly by both cell fibronectin interactions; as well as by insulin; in a PI3-K-dependent manner; probably through the binding of PtdIns(3;4;5)P3 with a PH-like domain of ILK.ILK1 over-expression has been documented in a wide variety of human malignancies.
- Aufreinigung:
- Greater than 95.0% as determined by SDS-PAGE.
- Versandbedingungen:
- Blue Ice
- Lagerbedingungen:
- Store at 4[o]C if entire vial will be used within 2-4 weeks. Store; frozen at -20[o]C for longer periods of time. Please avoid freeze thaw cycles.
- Hersteller:
- Abeomics
- Typ:
- Proteins, Peptides, Small Molecules & Other Biomolecules
- Datenblatt des Herstellers:1.jpg