GCK Recombinant Protein
Produktgrößen
10 µg
£528,00
32-3026-10UG
Über dieses Produkt
- SKU:
- 32-3026
- Zusätzliche Namen:
- Glucokinase||EC 2.7.1.2||Hexokinase-4||Hexokinase type IV||HK IV||HK4||Hexokinase-D||GCK||GK||GLK||HHF3||HKIV||HXKP||MODY2.
- Weitere Details:
- Source : Escherichia Coli. Glucokinase Human Recombinant produced in E.Coli is a single; non-glycosylated; polypeptide chain (aa 1-465) fused to a 20aa His tag at the N-terminal encoding the sequence of 485 amino acids and having a molecular mass of 54.3 kDa.HK4 is purified by proprietary chromatographic techniques. Hexokinases phosphorylate glucose to produce glucose-6-phosphate; thus committing glucose to the glycolytic pathway. Alternative splicing of Glucokinase results in three tissue-specific forms of glucokinase; one found in pancreatic islet beta cells and two found in liver. The protein localizes to the outer membrane of mitochondria. In contrast to other forms of hexokinase; HK4 is not inhibited by its product glucose-6-phosphate but remains active while glucose is abundant. Mutations in this gene have been associated with non-insulin dependent diabetes mellitus (NIDDM); maturity onset diabetes of the young; type 2 (MODY2) and persistent hyperinsulinemic hypoglycemia of infancy (PHHI).
- Aufreinigung:
- Greater than 95.0% as determined by SDS-PAGE.
- Versandbedingungen:
- Blue Ice
- Lagerbedingungen:
- Store at 4[o]C if entire vial will be used within 2-4 weeks.Store; frozen at -20[o]C for longer periods of time. For long term it is recommended to add a carrier protein (0.1% HSA or BSA). Please avoid freeze-thaw cycles.
- Hersteller:
- Abeomics
- Typ:
- Proteins, Peptides, Small Molecules & Other Biomolecules
- Datenblatt des Herstellers:1.jpg