FLT1 D7 Recombinant Protein
Produktgrößen
10 µg
£528,00
32-3017-10UG
Über dieses Produkt
- SKU:
- 32-3017
- Zusätzliche Namen:
- FLT-1||FLT1||Tyrosine-protein kinase receptor FLT||Flt-1||Tyrosine-protein kinase FRT||Fms-like tyrosine kinase 1||VEGFR-1.
- Weitere Details:
- Source : Insect Cells. Soluble FLT1 Human Recombinant fused with the Fc part of human IgG1 produced in baculovirus is disulfide-linked homodimeric; glycosylated; polypeptide containing 751 amino acids and having a molecular mass of 130 kDa. The soluble receptor protein contains only the first 7 extracellular domains (Met1-Thr751); which contain all the information necessary for high affinity ligand binding. The FLT1 fc/Chimera is purified by proprietary chromatographic techniques. Endothelial cells express three different vascular endothelial growth factor (VEGF) receptors; belonging to the family of receptor tyrosine kinases (RTKs). They are named VEGFR-1 (Flt-1); VEGFR-2 (KDR/Flk-1); and VEGFR-3 (Flt-4). Their expression is almost exclusively restricted to endothelial cells; but VEGFR-1 can also be found on monocytes. All VEGF-receptors have seven immunoglobulin-like extracellular domains; a single transmembrane region and an intracellular split tyrosine kinase domain. VEGFR-2 has a lower affinity for VEGF than the Flt-1 receptor; but a higher signalling activity. Mitogenic activity in endothelial cells is mainly mediated by VEGFR-2 leading to their proliferation. Differential splicing of the flt-1 gene leads to the formation of a secreted; soluble variant of VEGFR-1 (sVEGFR-1). No naturally occurring; secreted forms of VEGFR-2 have so far been reported. The binding of VEGF165 to VEGFR-2 is dependent on heparin.
- Aufreinigung:
- Greater than 95.0% as determined by SDS-PAGE.
- Versandbedingungen:
- Blue Ice
- Lagerbedingungen:
- Lyophilized FLT-1 although stable at room temperature for 3 weeks; should be stored desiccated below -18C. Upon reconstitution FLT1 should be stored at 4C between 2-7 days and for future use below -18C. For long term storage it is recommended to add a carrier protein (0.1% HSA or BSA). Please prevent freeze-thaw cycles.
- Hersteller:
- Abeomics
- Typ:
- Proteins, Peptides, Small Molecules & Other Biomolecules
- Datenblatt des Herstellers:1.jpg