FGFR1 Recombinant Protein
Produktgrößen
10 µg
£528,00
32-3006-10UG
Über dieses Produkt
- SKU:
- 32-3006
- Zusätzliche Namen:
- FGFR-1||bFGF-R||C-FGR||CD331||fms-related tyrosine kinase 2||Pfeiffer syndrome||CEK||FLG||FLT2||KAL2||BFGFR||FGFBR||HBGFR||FGFR1/FGFR1OP2 FUSION GENE||FGFR1/ZNF198 FUSION GENE||FLG FGFR1/BCR FUSION GENE||FLG protein||FMS-LIKE GENE||N-sam tyrosine kin
- Weitere Details:
- Source : Insect Cells. Soluble FGFR-1a (IIIc) Fc Chimera Human Recombinant fused with Xa cleavage site with the Fc part of human IgG1 produced in baculovirus is a heterodimeric; glycosylated; Polypeptide chain and having a molecular mass of 170 kDa. The FGFR1 is purified by proprietary chromatographic techniques. Fibroblast Growth Factors (FGFs) comprise a family of at least eighteen structurally realted proteins that are involved in a multitude of physiological and pathological cellular processes; including cell growth; differentation; angiogenesis; wound healing and tumorgenesis. The biological activities of the FGFs are mediated by a family if type I transmembrane tyrosine kinases which undergo dimerization and autophosphorylation after ligand binding. Four distinct genes encoding closely related FGF receptors; FGFR-1to -4 are known. Multiple forms of FGFR-1 to -3 are generated by alternative splicing of the mRNAs. A frequent splicing event involving FGFR-1 and -2 results in receptors containing all three Ig domains; referred to as the alpha isoform; or only IgII and IgIII; referred to as the alpha isoform. Only the alpha isoform has been identified for FGFR-3 and FGFR-4. Additional splicing events for FGFR-1 to -3; involving the C-terminal half of the IgIII domain encoded by two mutually exclusive alternative exons; generate FGF receptors with alternative IgIII domains (IIIb and IIIc). A IIIa isoform which is a secreted FGF binding protein containing only the N-terminal half of the IgIII domain plus some intron sequences has also been reported for FGFR-1. Mutations in FGFR-1 to -3 have been found in patients with birth defects involving craniosynostosis.
- Aufreinigung:
- Greater than 90.0% as determined by(a)Analysis by RP-HPLC.(b)Analysis by SDS-PAGE.
- Versandbedingungen:
- Blue Ice
- Lagerbedingungen:
- Lyophilized FGFR1A although stable at room temperature for 3 weeks; should be stored desiccated below -18[o]C. Upon reconstitution FGFR1 should be stored at 4[o]C between 2-7 days and for future use below -18[o]C.For long term storage it is recommended to add a carrier protein (0.1% HSA or BSA).Please prevent freeze-thaw cycles.
- Hersteller:
- Abeomics
- Typ:
- Proteins, Peptides, Small Molecules & Other Biomolecules
- Datenblatt des Herstellers:1.jpg