EGFR Sf9 Recombinant Protein
Produktgrößen
5 µg
£528,00
32-3002-5UG
Über dieses Produkt
- SKU:
- 32-3002
- Zusätzliche Namen:
- Epidermal growth factor receptor||EC 2.7.10.1||Receptor tyrosine-protein kinase ErbB-1||ERBB||mENA||ERBB1||EGFR.
- Weitere Details:
- Source : Baculovirus infected Sf9 cells. EGFR Human Recombinant encoding a.a. 672-1210 expressed in Baculovirus infected Sf9 cells; fused with a GST-tag at N-terminus with thrombin cleavage sites; having a molecular weight of 89;171 Dalton.EGFR is purified by proprietary chromatographic techniques. The epidermal growth factor receptor (EGF R) subfamily of receptor tyrosine kinases comprises four members: EGF R (also known as HER1; ErbB1 or ErbB); ErbB2 (Neu; HER-2); ErbB3 (HER-3); and ErbB4 (HER-4). All family members are type I transmembrane glycoprotein that has an extracellular domain which contains two cysteine-rich domains separated by a spacer region that is involved in ligand-binding; and a cytoplasmic domain which has a membrane-proximal tyrosine kinase domain and a C-terminal tail with multiple tyrosine autophosphorylation sites. The human EGF R gene encodes a 1210 amino acid (aa) residue precursor with a 24 aa putative signal peptide; a 621 aa extracellular domain; a 23 aa transmembrane domain; and a 542 aa cytoplasmic domain. EGF R has been shown to bind a subset of the EGF family ligands; including EGF; amphiregulin; TGF ; betacellulin; epiregulin; heparin-binding EGF and neuregulin-2 in the absence of a co-receptor. Ligand binding induces EGF R homodimerization as well as heterdimerization with ErbB2; resulting in kinase activation; tyrosine phosphorylation and cell signaling. EGF R can also be recruited to form heterodimers with the ligand-activated ErbB3 or ErbB4. EGF R signaling has been shown to regulate multiple biological functions including cell proliferation; differentiation; motility and apoptosis. In addition; EGF R signaling has also been shown to play a role in carcinogenesis.
- Versandbedingungen:
- Blue Ice
- Lagerbedingungen:
- Store vial at -20[o]C to -80[o]C. When stored at the recommended temperature; this protein is stable for 12 months. Please avoid freeze-thaw cycles.
- Hersteller:
- Abeomics
- Typ:
- Proteins, Peptides, Small Molecules & Other Biomolecules
- Datenblatt des Herstellers:1.jpg