EGFR Sf9 Recombinant Protein
Produktgrößen
10 µg
£528,00
32-3001-10UG
Über dieses Produkt
- SKU:
- 32-3001
- Zusätzliche Namen:
- Epidermal growth factor receptor||EC 2.7.10.1||Receptor tyrosine-protein kinase ErbB-1||ERBB||mENA||ERBB1||EGFR.
- Weitere Details:
- Source : Sf9 Insect Cells. The EGFR contains the extracellular domain of the human EGFR (25-647 a.a.) excluding the signal peptide which is cleaved by the insect cells having an approximate Mw of 85kDa. The EGFR is fused to a C-terminal Strep-tag and purified by proprietary chromatographic techniques. The epidermal growth factor receptor (EGF R) subfamily of receptor tyrosine kinases comprises four members: EGF R (also known as HER1; ErbB1 or ErbB); ErbB2 (Neu; HER-2); ErbB3 (HER-3); and ErbB4 (HER-4). All family members are type I transmembrane glycoprotein that has an extracellular domain which contains two cysteine-rich domains separated by a spacer region that is involved in ligand-binding; and a cytoplasmic domain which has a membrane-proximal tyrosine kinase domain and a C-terminal tail with multiple tyrosine autophosphorylation sites. The human EGF R gene encodes a 1210 amino acid (aa) residue precursor with a 24 aa putative signal peptide; a 621 aa extracellular domain; a 23 aa transmembrane domain; and a 542 aa cytoplasmic domain. EGF R has been shown to bind a subset of the EGF family ligands; including EGF; amphiregulin; TGF ; betacellulin; epiregulin; heparin-binding EGF and neuregulin-2 in the absence of a co-receptor. Ligand binding induces EGF R homodimerization as well as heterdimerization with ErbB2; resulting in kinase activation; tyrosine phosphorylation and cell signaling. EGF R can also be recruited to form heterodimers with the ligand-activated ErbB3 or ErbB4. EGF R signaling has been shown to regulate multiple biological functions including cell proliferation; differentiation; motility and apoptosis. In addition; EGF R signaling has also been shown to play a role in carcinogenesis.
- Aufreinigung:
- Greater than 90.0% as determined by SDS-PAGE.
- Versandbedingungen:
- Blue Ice
- Lagerbedingungen:
- Lyophilized EGFR although stable at room temperature for 3 weeks; should be stored desiccated below -18[o]C. Upon reconstitution EGFR should be stored at 4[o]C between 2-7 days and for future use below -18[o]C.For long term storage it is recommended to add a carrier protein (0.1% HSA or BSA).Please prevent freeze-thaw cycles.
- Hersteller:
- Abeomics
- Typ:
- Proteins, Peptides, Small Molecules & Other Biomolecules
- Datenblatt des Herstellers:1.jpg