PSMA7 Recombinant Protein
Produktgrößen
50 µg
£528,00
32-2746-50UG
Über dieses Produkt
- SKU:
- 32-2746
- Zusätzliche Namen:
- HSPC||RC6-1||XAPC7||MGC3755||PSMA-7||Proteasome subunit alpha type-7||Proteasome subunit RC6-1||Proteasome subunit XAPC7||PSMA7||C6.
- Weitere Details:
- Source : Escherichia Coli. PSMA7 Human Recombinant fused to N-terminal His-Tag produced in E.Coli is a single; non-glycosylated polypeptide chain containing 268 amino acids (1-248) and having a molecular mass of 30kDa. PSMA7 is fused to a 20 amino acid His Tag at N-Terminus and purified by standard chromatography techniques. The proteasome is a multicatalytic proteinase complex with a highly assembled ring-shaped 20S core structure which is composed of 4 rings of 28 non-identical subunits; 2 rings are composed of 7 alpha subunits and 2 rings are composed of 7 beta subunits. Proteasomes are found throughout eukaryotic cells at a high concentration and cleave peptides in an ATP/ubiquitin-dependent process in a non-lysosomal pathway. PSMA7 is part of the peptidase T1A family; that is a 20S core alpha subunit. PSMA7 interacts particularly with the hepatitis B virus X protein; a protein critical to viral replication. PSMA7 is involved in regulating hepatitis virus C internal ribosome entry site activity that is crucial for viral replication. PSMA7 is in charge for regulating the hypoxia-inducible factor-1alpha; a transcription factor important for cellular responses to oxygen tension. PSMA7 is characterized by its ability to cleave peptides with Arg; Phe; Tyr; Leu; and Glu adjacent to the leaving group at neutral or slightly basic pH. PSMA7 interacts specifically with two subdomains of HIF-1alpha and inhibited the transactivation function of HIF-1alpha under both normoxic and hypoxia-mimicking conditions.
- Aufreinigung:
- Greater than 90.0% as determined SDS-PAGE.
- Versandbedingungen:
- Blue Ice
- Lagerbedingungen:
- PSMA7 although stable 4[o]C for 4 weeks; should be stored desiccated below -18[o]C. For long term storage it is recommended to add a carrier protein (0.1% HSA or BSA).Please prevent freeze-thaw cycles.
- Hersteller:
- Abeomics
- Typ:
- Proteins, Peptides, Small Molecules & Other Biomolecules
- Datenblatt des Herstellers:1.jpg